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TranscriptomicsChemokine expression in retinal pigment epithelial cells in response to co-culture with activated T Cells
Purpose: To investigate the effects of T cell-derived cytokines on gene and protein expression of chemokines in a human RPE cell line (ARPE-19). Methods: We used an in vitro co-culture system in which the RPE and CD3/28-activated T cells were separated by a membrane. Differential gene expression in...
ORGANISM(S): Homo sapiens 
2012-11-19 | E-GEOD-36331 | biostudies-arrayexpress
TranscriptomicsComplement Factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.
Purpose: The complement system is closely linked to the pathogenesis of age-related macular degeneration (AMD). Several complement genes are expressed in retinal pigment epithelium (RPE), and complement proteins accumulate in drusen. Further, a common variant of complement factor H (CFH) confers inc...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-38671 | biostudies-arrayexpress
TranscriptomicsInflammation-induced chemokine expression in uveal melanoma cell lines stimulates monocyte chemotaxis
Purpose: Uveal melanoma (UM) is the most common primary intraocular tumor in adults and the presence of infiltrating leucocytes is associated with a poor prognosis. Little is known how infiltrating leucocytes influence the tumor cells. The purpose of this study was to investigate the effect of activ...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-55983 | biostudies-arrayexpress
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