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ProteomicsInteractome of EWS::FLI1 fusion protein expressed in Saccharomyces cerevisiae identified by co-immunoprecipitation and mass spectrometry (co-IP/MS)
Ewing sarcoma (EwS) is an aggressive, human-exclusive tumor typically driven by the EWS::FLI1 fusion protein. To assess whether the neomorphic functions of EWS::FLI1 are fundamentally dependent on evolutionarily recent cofactors such as ETS transcription factors (ETS-TFs), Polycomb group (PcG) prote...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-10-26 | PXD079390 | Pride
Fact complex ets transcription factors Ews::fli1 Saccharomyces cerevisiae Baf/swi-snf Ewing sarcoma Saga complex 
GenomicsTherapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (RNA-Seq II)
Therapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (RNA-Seq II)
PRJNA802204 | ENA
GenomicsTherapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (RNA-Seq I)
Therapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (RNA-Seq I)
PRJNA802205 | ENA
GenomicsTherapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (ChIP-Seq)
Therapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (ChIP-Seq)
PRJNA802206 | ENA
GenomicsTherapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (ChIP-Seq)
EWS/ETS fusion transcription factors, most commonly EWSR1-FLI1, drive initiation and progression of Ewing sarcoma (EwS), a highly aggressive childhood cancer of bone and soft tissues. Even though direct targeting EWSR1-FLI1 is a formidable challenge, epigenetic or transcriptional modulators have bee...
ORGANISM(S): Homo sapiens 
2022-12-31 | GSE195802 | GEO
TranscriptomicsTherapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (RNA-Seq II)
EWS/ETS fusion transcription factors, most commonly EWSR1-FLI1, drive initiation and progression of Ewing sarcoma (EwS), a highly aggressive childhood cancer of bone and soft tissues. Even though direct targeting EWSR1-FLI1 is a formidable challenge, epigenetic or transcriptional modulators have bee...
ORGANISM(S): Homo sapiens 
2022-12-31 | GSE195804 | GEO
TranscriptomicsTherapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (RNA-Seq I)
EWS/ETS fusion transcription factors, most commonly EWSR1-FLI1, drive initiation and progression of Ewing sarcoma (EwS), a highly aggressive childhood cancer of bone and soft tissues. Even though direct targeting EWSR1-FLI1 is a formidable challenge, epigenetic or transcriptional modulators have bee...
ORGANISM(S): Homo sapiens 
2022-12-31 | GSE195803 | GEO
UnknownMultiple ETS Factors Participate in the Transcriptional Control of TERT Mutant Promoter in Thyroid Cancers.
Not available
S-EPMC8774187 | biostudies-literature
TranscriptomicsThe faint sausage gene encodes a subunit of the spliceosome-activating Prp19 complex and is required for tracheal branching morphogenesis in Drosophila
Morphogenesis requires the dynamic regulation of gene expression, including transcription, mRNA maturation and translation. Dysfunction of general components of the splicing machinery can cause surprisingly specific phenotypes, but the basis for these cell-type specific effects is not clear. Here we...
ORGANISM(S): Drosophila melanogaster 
2016-11-18 | E-MTAB-5069 | biostudies-arrayexpress
TranscriptomicsCharacterization of the starvation response in the Arabidopsis dcl1-9 mutant
The SnRK1 protein kinase, the plant ortholog of mammalian AMPK and yeast Snf1, is activated by the energy depletion caused by adverse environmental conditions. Upon activation, SnRK1 triggers extensive transcriptional changes to restore homeostasis and promote stress tolerance and survival partly th...
ORGANISM(S): Arabidopsis thaliana 
2013-07-15 | E-GEOD-46713 | biostudies-arrayexpress
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