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ModelsPhosphatase activities on PI(3,4,5)P3 and PI(3,4)P2
Phosphatase activities on PI(3,4,5)P3 and PI(3,4)P2 This model describes the action of various phosphatases on PI(3,4,5)P3 and PI(3,4)P2, in response to a stimulation by EGF. It contains boolean switches to simulate knock-down and knock-out of phosphatases as well as inhibition of PI3 kinase. ...
MODEL1704190000 | BioModels
GenomicsAn Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes (ChIP-Seq)
Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that suppress transposons and enable gamete maturation. Mammalian transposon-silencing piRNAs accumulate early in spermatogenesis, whereas pachytene piRNAs are produced later during post-natal spermatogenesis and account ...
ORGANISM(S): Mus musculus 
2013-03-26 | E-GEOD-44588 | biostudies-arrayexpress
TranscriptomicsAn Ancient Transcription Factor An Ancient Transcription Factor During Early Meiosis in Mouse Testes (PAS-Seq and CAGE)
Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that suppress transposons and enable gamete maturation. Mammalian transposon-silencing piRNAs accumulate early in spermatogenesis, whereas pachytene piRNAs are produced later during post-natal spermatogenesis and account ...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-45048 | biostudies-arrayexpress
TranscriptomicsInduction of IL-17+ T-cells by HIV-Tat protein is mediated via Vascular Endothelial Growth Factor Receptor-2
Anti-retroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection from a fatal illness to a chronic condition by controlling viral replication and restoring immune function. However, chronic T-cell activation can be observed in 20-35% of individuals on ART, resulting in an i...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-44460 | biostudies-arrayexpress
UnknownMechanism of Phosphatidylserine Lipid Scrambling by Human SERINC3, an HIV-1 Restriction Factor.
Not available
S-EPMC12642633 | biostudies-literature
ProteomicsProtein microarray analysis of antibody responses to Plasmodium falciparum in Western Kenyan highlands
Malaria represents a major public health problem in Africa [1]. In the East African highlands, even in high-altitude areas previously considered too cold to support vector population and parasite transmission [2], frequent malaria epidemics have been reported since the 1980M-bM-^@M-^Ys [3]. Plasmodi...
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-48089 | biostudies-arrayexpress
Transcriptomicsadipose tissue gene expression profile from male WT and fat-1 transgenic 14 week old high fat fed mice
Dietary administration of n-3 polyunsaturated fatty acids (PUFA) is often associated with altered adipose tissue (AT) morphology and/or function in obese mice. However, it is unclear whether these observations are an indirect consequence of reduced weight gain or result from direct actions of n-3 PU...
ORGANISM(S): Mus musculus 
2015-02-06 | E-MTAB-1831 | biostudies-arrayexpress
UnknownThe 100 Most Cited Androgenetic Alopecia Articles: An Analysis of Altmetrics Data from 2015 to 2022.
Not available
S-EPMC11460846 | biostudies-literature
ProteomicsRetinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina
Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the loss of the retinal pigment epithelium (RPE) and photoreceptors and/or retinal and choroidal angiogenesis. Here we use AMD patient specific RPE cells with the Y402H high-risk polymorphism in the comp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-21 | MSV000088713 | MassIVE
GenomicsTranscription factor trapping by RNA in gene regulatory elements (ChIP-Seq)
Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both promoter-proximal and distal DNA elements, and some DNA-binding TFs have also been shown to bind RNA. These obsevations led us to p...
ORGANISM(S): Mus musculus 
2015-05-28 | E-GEOD-68195 | biostudies-arrayexpress
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