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TranscriptomicsBreast tumors from CHEK2 1100delC mutation carriers: genomic landscape and clinical implications (CGH)
Abstract Introduction: CHEK2 is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about two fold. We pursued to investigate gene copy number aberrations and gene expression profiles that are typical for breast tumors of CHEK2 1100delC mutation carri...
ORGANISM(S): Homo sapiens 
2011-05-10 | E-GEOD-24698 | biostudies-arrayexpress
TranscriptomicsBreast tumors from CHEK2 1100delC mutation carriers: genomic landscape and clinical implications (GEX)
Introduction: CHEK2 is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about two fold. We pursued to investigate gene copy number aberrations and gene expression profiles that are typical for breast tumors of CHEK2 1100delC mutation carriers. Mat...
ORGANISM(S): Homo sapiens 
2011-05-10 | E-GEOD-24697 | biostudies-arrayexpress
TranscriptomicsThe retinoblastoma gene is targeted for rearrangements in BRCA1-deficient basal-like breast cancer.
Breast tumors from BRCA1 germ line mutation carriers typically exhibit features of the basal-like molecular subtype. However, the specific genes recurrently mutated as a consequence of BRCA1 dysfunction have not been fully elucidated. In this study, we utilized gene expression profiling to molecular...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-25307 | biostudies-arrayexpress
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