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TranscriptomicsTranscription profiling of mouse metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice
Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice usi...
ORGANISM(S): Mus musculus 
2004-09-01 | E-MEXP-150 | biostudies-arrayexpress
TranscriptomicsAge-associated alteration of gene expression patterns in mouse oocytes
Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice us...
ORGANISM(S): Mus musculus 
2010-06-06 | E-GEOD-1646 | biostudies-arrayexpress
TranscriptomicsEffects of Aging and Calorie Restriction on the Global Gene Expression Profiles of Mouse Testis and Ovary
AGEMAP is an initiative of the National Institute on Aging (NIA) designed to study the aging process on mice with Caloric Restriction (CR) versus Ad Libitum (AL) diet. The aim of the AGEMAP project is to provide a valuable source of information about genetic influences involved in aging of the major...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-7502 | biostudies-arrayexpress
TranscriptomicsRejuvenation of pluripotent stem cells by frequent activation of Zscan4, Part A
The gold standard for examining pluripotency of stem cells is to see whether cells can contribute to entire body of animals. Here we show that the increased frequency of Zscan4 activation in mouse ES cells not only enhances, but also maintains their developmental potency in long-term cell culture. A...
ORGANISM(S): Mus musculus 
2013-06-12 | E-GEOD-15604 | biostudies-arrayexpress
TranscriptomicsRejuvenation of pluripotent stem cells by frequent activation of Zscan4
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-12 | E-GEOD-26278 | biostudies-arrayexpress
TranscriptomicsRejuvenation of pluripotent stem cells by frequent activation of Zscan4, Part B
The gold standard for examining pluripotency of stem cells is to see whether cells can contribute to entire body of animals. Here we show that the increased frequency of Zscan4 activation in mouse ES cells not only enhances, but also maintains their developmental potency in long-term cell culture. A...
ORGANISM(S): Mus musculus 
2013-06-12 | E-GEOD-26162 | biostudies-arrayexpress
TranscriptomicsTimed induction of 50 transcription factors in ES cells reveals a common mechanism to initiate differentiations
To decipher the structure and behaviors of the transcription factor (TF) network, we created 50 permanent mouse ES cell lines, in each of which one of the 50 transcription factors tagged with FLAG, is inserted into the doxycycline (dox)-repressible ROSA26 locus. Expression profiling reveals Cdx2 as ...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-14559 | biostudies-arrayexpress
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