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GenomicsmTORC1 couples SREBP-dependent transcription and splicing of de novo lipid synthesis enzymes via FAM120A de novo lipid synthesis enzymes via FAM120A
mTORC1 couples SREBP-dependent transcription and splicing of de novo lipid synthesis enzymes via FAM120A de novo lipid synthesis enzymes via FAM120A
PRJNA854056 | ENA
GenomicsSequestration of microRNA-mediated target repression by the Ago2-associated RNA binding protein FAM120A
Sequestration of microRNA-mediated target repression by the Ago2-associated RNA binding protein FAM120A
PRJNA526904 | ENA
UnknownFAM120A deficiency improves resistance to cisplatin in gastric cancer by promoting ferroptosis.
Not available
S-EPMC10987584 | biostudies-literature
GenomicsFAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
PRJNA955239 | ENA
TranscriptomicsmTORC1 couples SREBP-dependent transcription and splicing of de novo lipid synthesis enzymes via FAM120A de novo lipid synthesis enzymes via FAM120A
FAM120A as a transcriptional co-activator that couples transcription and splicing of lipid synthesis enzymes downstream of mTORC1-SRPK2 signaling. Mechanistically, the mTORC1-activated SRPK2 phosphorylates a splicing factor SRSF1, enhancing its binding to FAM120A. FAM120A directly interacts with a l...
ORGANISM(S): Homo sapiens 
2022-07-02 | GSE207172 | GEO
UnknownSequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A.
Not available
S-EPMC6800481 | biostudies-literature
UnknownFAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.
Not available
S-EPMC10494788 | biostudies-literature
OtherSequestration of microRNA-mediated target repression by the Ago2-associated RNA binding protein FAM120A
Argonaute (Ago) proteins interact with various binding partners and play a pivotal role in microRNA (miRNA)-mediated silencing pathways. By utilizing immunoprecipitation followed by mass spectrometry to determine cytoplasmic Ago2 protein complexes in mouse embryonic stem cells (mESCs), we identified...
ORGANISM(S): Mus musculus 
2019-07-09 | GSE128264 | GEO
TranscriptomicsFAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that stimulates macromolecule synthesis via insulin, growth factors, and oncogenic signals. mTORC1 activates anabolic pathways by inducing posttranslational modifications of metabolic enzymes, and by regulati...
ORGANISM(S): Homo sapiens 
2023-09-01 | GSE229657 | GEO
UnknownLoss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference.
Not available
S-EPMC11381323 | biostudies-literature
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