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MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
ProteomicsProteomics data of extracellular vesicles, which are specifically derived from testicular macrophage cells within the mouse testis, offer detailed and comprehensive insights into the unique biochemical compositions and potential roles of these vesicles in the testicular microenvironment.
Testosterone synthesis in male mammals occurs predominantly in testicular Leydig cells (LCs), a process that is energetically demanding and results in cellular component damage. Despite this, LCs are long-lived and rarely renew, suggesting the presence of specialized mechanisms to maintain LCs homeo...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-24 | PXD059652 | Pride
Testicular macrophage cells -evs 
ProteomicsProteomics data of extracellular vesicles, which are specifically derived from Leydig cells or testicular macrophage cells respectively within the mouse testis, offer detailed and comprehensive insights into the unique biochemical compositions and potential roles of these vesicles in the testicular microenvironment.
Testosterone synthesis in male mammals occurs predominantly in testicular Leydig cells (LCs), a process that is energetically demanding and results in cellular component damage. Despite this, LCs are long-lived and rarely renew, suggesting the presence of specialized mechanisms to maintain LCs homeo...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-24 | PXD059780 | Pride
Leydig cells-evs 
UnknownRegulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress.
Not available
S-EPMC10614380 | biostudies-literature
TranscriptomicsCircadian patterns of gene expression in the human brain and disruption in major depressive disorder
A cardinal symptom of Major Depressive Disorder (MDD) is the disruption of circadian patterns. Yet, to date, there is no direct evidence of circadian clock dysregulation in the brains of MDD patients. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues,...
ORGANISM(S): Homo sapiens 
2013-04-20 | E-GEOD-45642 | biostudies-arrayexpress
UnknownThe deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation
Not available
S-SCDT-EMBOR-2020-50308-T | biostudies-other
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