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MetabolomicsSimultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics
Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an opportunity to simultaneously gain deep insights int...
2023-07-03 | MTBLS2746 | MetaboLights
ProteomicsMulti-functions of McHB7 in Mesembryanthemum crystallinum responses to salt and drought stresses
Mesembryanthemum crystallinum (common ice plant) is one of the most important halophyte plants for plant stress biology research. In this study, we established an efficient Agrobacterium-mediated transformation method in ice plant and confirmed that ice plant can sustain gene overexpression for four...
ORGANISM(S): Mesembryanthemum crystallinum (Common ice plant) (Cryophytum crystallinum) 
2024-05-21 | PXD033521 | Pride
Salt stress  drought stress  proteomics 
MetabolomicsLinking soil biology and chemistry in biological soil crust using isolate exometabolomics
Metagenomic sequencing provides a window into microbial community structure and metabolic potential; however, linking these data to exogenous metabolites that microorganisms process and produce (the exometabolome) remains challenging. Previously, we observed strong exometabolite niche partitioning a...
2018-07-31 | MTBLS492 | MetaboLights
ProteomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity
The programmed cell death protein 1 (PD-1) / programmed death-ligand 1 (PD-L1) axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingo...
ORGANISM(S): Homo Sapiens 
2026-02-27 | PXD075012 |
UnknownMultiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis.
Not available
S-EPMC9886551 | biostudies-literature
UnknownlncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
Not available
S-EPMC6143179 | biostudies-literature
UnknownThe landscape of viral associations in human cancers.
Not available
S-EPMC8076016 | biostudies-literature
UnknownPerceptions of science, science communication, and climate change attitudes in 68 countries - the TISP dataset.
Not available
S-EPMC11747281 | biostudies-literature
UnknownComprehensive molecular portraits of human breast tumours.
Not available
S-EPMC3465532 | biostudies-literature
UnknownThe somatic genomic landscape of chromophobe renal cell carcinoma.
Not available
S-EPMC4160352 | biostudies-literature
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