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GenomicsFarnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate
Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate
PRJNA1003090 | ENA
TranscriptomicsFarnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis. Reduced PGC-1α abundance is linked to skeletal muscle weakness in aging or pathological conditions; thus, elevating PGC-1α abundance might be a promising strategy to treat muscle a...
ORGANISM(S): Mus musculus 
2023-08-12 | GSE240281 | GEO
UnknownPARIS farnesylation prevents neurodegeneration in models of Parkinson's disease.
Not available
S-EPMC9990146 | biostudies-literature
GenomicsMutation-Agnostic Base Editing of the Progerin Farnesylation Site Rescues Hutchinson-Gilford Progeria Syndrome Phenotypes in Neuromuscular Organoids
Mutation-Agnostic Base Editing of the Progerin Farnesylation Site Rescues Hutchinson-Gilford Progeria Syndrome Phenotypes in Neuromuscular Organoids
PRJNA1304889 | ENA
TranscriptomicsMutation-Agnostic Base Editing of the Progerin Farnesylation Site Rescues Hutchinson-Gilford Progeria Syndrome Phenotypes in Neuromuscular Organoids
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, fatal premature aging disorder caused by a de novo mutation in the LMNA gene that leads to the production of progerin, a farnesylated, pathogenic form of lamin A. Treatment with farnesyltransferase inhibitors achieves significant yet limited lif...
ORGANISM(S): Homo sapiens 
2026-07-13 | GSE305237 | GEO
TranscriptomicsA defect in protein farnesylation suppresses a loss of fission yeast tsc2
Human Tsc1 and Tsc2 genes predispose to Tuberous Sclerosis Complex (TSC), a disorder characterized by the widespread of benign tumors. Tsc1 and Tsc2 proteins form a complex and serve as a GAP (GTP activating protein) for Rheb, a GTPase regulating a downstream kinase, mTor. The fission yeast genome c...
ORGANISM(S): Schizosaccharomyces pombe 
2006-06-13 | GSE4449 | GEO
UnknownProtein Farnesylation Takes Part in Arabidopsis Seed Development.
Not available
S-EPMC7876099 | biostudies-literature
UnknownIdentification of a novel class of farnesylation targets by structure-based modeling of binding specificity.
Not available
S-EPMC3188499 | biostudies-literature
UnknownCoordinated cell motility is regulated by a combination of LKB1 farnesylation and kinase activity.
Not available
S-EPMC5244416 | biostudies-literature
UnknownZebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity.
Not available
S-EPMC3082311 | biostudies-literature
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