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TranscriptomicsExpression data from normal human fibroblasts expressing prelamin A or progerin, untreated or treated with farnesyltransferase inhibitor (FTI)
We compared the transcriptomes of isogenic diploid fibroblasts expressing progerin or elevated levels of wild-type prelamin A with that of wild-type fibroblasts. We subsequently used the reversion towards normal of two phenotypes, reduced cell growth and dismorphic nuclei, by treatment with farnesyl...
ORGANISM(S): Homo sapiens 
2012-08-31 | E-GEOD-40404 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblasts from patients with HGPS compared to age matched controls treated both control and HGPS fibroblasts with a protein farnesyltransferase inhibitor (FTI)
We analyzed and compared global gene expression changes in fibroblasts from human subjects with HGPS compared to age matched controls. We then treated both control and HGPS fibroblasts with a protein farnesyltransferase inhibitor (FTI), a medication currently used in clinical trials to treat HGPS, ...
ORGANISM(S): Homo sapiens 
2010-06-01 | E-MEXP-2597 | biostudies-arrayexpress
UnknownEffect of Farnesyltransferase Inhibitor R115777 on Mitochondria of Plasmodium falciparum.
Not available
S-EPMC4566515 | biostudies-literature
TranscriptomicsExpression data from normal human fibroblasts expressing prelamin A or progerin, untreated or treated with farnesyltransferase inhibitor (FTI)
We compared the transcriptomes of isogenic diploid fibroblasts expressing progerin or elevated levels of wild-type prelamin A with that of wild-type fibroblasts. We subsequently used the reversion towards normal of two phenotypes, reduced cell growth and dismorphic nuclei, by treatment with farnesyl...
ORGANISM(S): Homo sapiens 
2012-08-31 | GSE40404 | GEO
TranscriptomicsTranscription profiling of human acute myeloid leukemia samples - a two-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib
Currently there is no method available to predict response to farnesyltransferase inhibitors (FTI). We analyzed gene expression profiles from the bone marrow of patients from a phase 2 study of the FTI tipifarnib, in older adults with previously untreated acute myeloid leukemia (AML). The RASGRP1:AP...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8970 | biostudies-arrayexpress
UnknownClinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome.
Not available
S-EPMC3478615 | biostudies-literature
UnknownFarnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells.
Not available
S-EPMC3245614 | biostudies-literature
UnknownFarnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
Not available
S-EPMC3226365 | biostudies-literature
UnknownThe protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.
Not available
S-EPMC3265986 | biostudies-literature
UnknownFarnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras.
Not available
S-EPMC6070134 | biostudies-literature
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