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ProteomicsComprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C—H Functionalization
The plant-derived sesquiterpene lactone micheliolide was recently found to possess promising antileukemic activity, including the ability to target and kill leukemia stem cells. Efforts toward improving the biological activity of micheliolide and investigating its mechanism of action have been hinde...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024455 | Pride
Competitive pull-down Multi-probe proteomics Leukemia stem cells C-h functionalization Biocatalysis Sesquiterpene lactones 
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