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ModelsWebb2002 - Fas/FasL mediated tumor T-cell interaction
Webb2002 - Fas/FasL mediated tumor T-cell interaction This deterministic model of immunological surveillance involving tumour cell–T-lymphocyte interaction, cell surface expression of Fas/FasL, and their secreted soluble forms. This model is described in the article: Cells behaving badly: ...
2024-09-02 | BIOMD0000000661 | BioModels
TranscriptomicsSpontaneous Elimination of Intraocular Tumors is Associated with IFNγ- and Fas/FasL-Dependent Activation of Macrophages
Ocular immune privilege (IP) limits immune surveillance of intraocular tumors as certain immunogenic tumor cell lines (P815, E.G7-OVA) that are rejected when transplanted in the skin grow progressively when placed in the anterior chamber (a.c.) of the eye. As splenectomy (SPLNX) is known to terminat...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-57101 | biostudies-arrayexpress
GenomicsRNASeq-based identification of extracellular matrix components impacted by FasL deficiency in osteoblasts
RNASeq-based identification of extracellular matrix components impacted by FasL deficiency in osteoblasts
PRJNA1054612 | ENA
GenomicsExpression data (U133 Plus 2.0) from fibroblast like synoviocytes from patients with rheumatoid arthritis (RA-FLS) stimulated by FasL
Expression data (U133 Plus 2.0) from fibroblast like synoviocytes from patients with rheumatoid arthritis (RA-FLS) stimulated by FasL
PRJNA642862 | ENA
TranscriptomicsExpression data (U133 Plus 2.0) from fibroblast like synoviocytes from patients with rheumatoid arthritis (RA-FLS) stimulated by FasL
Fas ligand (FasL)/TNFSF6, a member of the tumor necrosis factor (TNF) superfamily, can promote apoptosis in activated primary B cells, T cells, dendritic cells, and synovial fibroblasts through Fas and is involved in the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA). Meanwh...
ORGANISM(S): Homo sapiens 
2020-06-30 | GSE153378 | GEO
TranscriptomicsRNASeq-based identification of extracellular matrix components impacted by FasL deficiency in osteoblasts
Osteoblasts and osteoclasts are two critical cell populations in bone remodelling. FasL is known from osteoblast-induced osteoclast apoptosis. Notably, FasL deficient (gld) mice display increased bone mass pointing to non-apoptotic functions of FasL. Some key extracellular matrix associated molecule...
ORGANISM(S): Mus musculus 
2025-10-16 | GSE250608 | GEO
UnknownHuman FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions.
Not available
S-EPMC3191176 | biostudies-literature
GenomicsA PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4 T helper cell signaling and differentiation.
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4 T helper cell signaling and differentiation.
PRJNA1166676 | ENA
UnknownLocalized immune tolerance from FasL-functionalized PLG scaffolds.
Not available
S-EPMC6331284 | biostudies-literature
TranscriptomicsSpontaneous Elimination of Intraocular Tumors is Associated with IFNγ- and Fas/FasL-Dependent Activation of Macrophages
Ocular immune privilege (IP) limits immune surveillance of intraocular tumors as certain immunogenic tumor cell lines (P815, E.G7-OVA) that are rejected when transplanted in the skin grow progressively when placed in the anterior chamber (a.c.) of the eye. As splenectomy (SPLNX) is known to terminat...
ORGANISM(S): Mus musculus 
2014-07-01 | GSE57101 | GEO
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