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TranscriptomicsTranscription profiling of thermosensitive exosome mutants from permissive temperature and various time exposure to restrictive temperature
Transcriptome analyses of thermosensitive exosome mutants from permissive temperature to various time exposure to restrictive temperature.
ORGANISM(S): Saccharomyces cerevisiae 
2006-02-28 | E-MEXP-537 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human breast cancer cell line MDA-MB-231 treated with STM2457 against untreated controls
Here, we aim to investigate if catalytic inhibition of the m6A methyltransferase METTL3 by the small-molecule STM2457 may be a viable treatment option for TNBC.
ORGANISM(S): Homo sapiens 
2023-12-18 | E-MTAB-13184 | biostudies-arrayexpress
TranscriptomicsRNA-seq of K562 cells treated with the FTO inhibitor CS2 compared to DMSO treated cells
Increased FTO expression has been connected to resistance to tyrosine kinase inhibitors in CML. To explore the therapeutic potential of targeting FTO in CML, we tested the FTO catalytic inhibitor in the K562 CML cell line. The RNA-seq was performed to identify relevant regulated genes.
ORGANISM(S): Homo sapiens 
2023-12-31 | E-MTAB-12774 | biostudies-arrayexpress
TranscriptomicsRNA-seq of K562 cells treated with the FTO inhibitor FB23-2
FB23-2 inhibits proliferation of K562 cells. The RNA-seq was performed to identify relevant regulated genes.
ORGANISM(S): Homo sapiens 
2023-12-01 | E-MTAB-11751 | biostudies-arrayexpress
TranscriptomicsIdentification of transcripts regulated by CEBPA protein and its P30 isoform in K562
To investigate the effect of CEBPA and its mutant isoform P30 on the expression of mRNAs and long non-coding RNAs (lncRNAs), we utilized the K562 AML cell line carrying a stable and Tet-on inducible CEBPA or P30 allele. Based on the expression of known CEBPA transcriptional targets, we selected RNA...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-65235 | biostudies-arrayexpress
TranscriptomicsIdentification of transcripts regulated by CEBPA in K562
To investigate the effect of CEBPA on the expression of mRNAs and long non-coding RNAs ( lncRNAs), we utilized the K562 AML cell line carrying a stable and Tet-on inducible CEBPA allele. K562 cells lack endogenous CEBPA and restoration of its expression induces proliferation arrest and granulocytic ...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-58743 | biostudies-arrayexpress
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