Sort   by:  
 Page size 
MetabolomicsSCUBE3 enhances post-myocardial infarction angiogenesis by promoting endothelial fatty acid metabolism

BACKGROUND: Myocardial infarction (MI), one of the leading causes of mortality worldwide, remains a clinical challenge due to limitations in current therapeutic strategies. The cardiac vascular network, as the fundamental architecture sustaining myocardial function, delivers oxygen and nutrients ...

2025-09-18 | MTBLS13005 | MetaboLights
MetabolomicsFatty acid synthesis in colorectal cancer: characterization of lipid metabolism in serum, tumour, and normal host tissues
The objective of the experiment was to compare serum fatty acid metabolite abundance between individuals with varying clinical stages of colorectal cancer (stage I-IV) and age-and-gender matched disease-free controls. Fatty acid metabolite abundance was compared between locoregional (stage I-III) an...
2016-12-15 | MTBLS27 | MetaboLights
MetabolomicsHost–gut microbiota–bile acid axis integrates dietary starch to regulate milk fatty acid metabolism in dairy goats

Bile acids (BA) and BA-related microbiota are essential for ruminant lipid metabolism, yet targeted modulation to enhance production and health remain underexplored. Herein, we investigated the interplay between dietary rumen degradable starch, BA metabolism, and milk fatty acids (FAs) synthesis...

2025-12-09 | MTBLS13483 | MetaboLights
MetabolomicsLC-MS-based isotope tracing data supporting cholesterol- and EA2-regulated fatty acid synthesis and tumor metabolic remodeling
This study contains LC-MS-based stable isotope tracing data investigating cholesterol- and EA2-regulated tumor metabolic remodeling. The dataset includes U-13C-glucose tracing in tumor cells and D2O tracing in animal models, supporting analysis of cholesterol-driven metabolic remodeling and the supp...
2026-10-03 | MTBLS14937 | MetaboLights
MetabolomicsIncreased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke
The goal of this study was to evaluate changes in metabolic homeostasis during the first 12 weeks of recovery in a distal middle cerebral artery occlusion mouse model of stroke. To achieve this goal, we compared the brain metabolomes of ipsilateral and contralateral hemispheres from aged male mice u...
2022-10-06 | MTBLS5543 | MetaboLights
MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
MetabolomicsHow Does the Seed Pre-germinative Metabolism Fight against Imbibition Damage? Emerging Roles of Fatty Acid Cohort and Antioxidant Defence

During seed imbibition, lipids are engaged in membrane reorganization while facing free radical-mediated oxidative injury. In the present work, we explored changes in lipid components at different timepoints of imbibition (0.5, 2, 4, 6, and 8 h) in the legume Medicago truncatula, by combining bio...

2019-10-14 | MTBLS181 | MetaboLights
MetabolomicsOregano essential oil-driven rumen microbiome metabolism potentially regulates intramuscular fatty acid profile in Holstein bulls through liver lipid metabolism

Abstract

Background

While oregano essential oil (OEO) has been used as a feed additive in ruminant production and shown to positively influence meat quality, its effects on the rumen microbiota and host liver metabolism, and the potential mechanisms linking these to intramuscular fat...

2025-12-15 | MTBLS13490 | MetaboLights
MetabolomicsSCUBE3 enhances post-myocardial infarction angiogenesis by promoting endothelial fatty acid metabolism.

BACKGROUND: Myocardial infarction (MI), one of the leading causes of mortality worldwide, remains a clinical challenge due to limitations in current therapeutic strategies. The cardiac vascular network, as the fundamental architecture sustaining myocardial function, delivers oxygen and nutrients ...

2025-09-18 | MTBLS13004 | MetaboLights
Sort   by:  
 Page size