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GenomicsLoss of Tet enzymes compromises proper differentiation of embryonic stem cells
Tet enzymes (Tet1/2/3) catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and are dynamically expressed in various embryonic and adult cell types. While loss of individual Tet enzymes or combined deficiency of Tet1/2 allows for embryogenesis, the effect of complete ...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-55049 | biostudies-arrayexpress
Unknown[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.
Not available
S-EPMC4839461 | biostudies-literature
GenomicsCombined deficiency of Tet1 and Tet2 is compatible with development but leads to epigenetic instability
Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 and Tet2 mediate 5hmC generation in mouse embryonic stem cells (ESCs) and various embryonic and adult tissues. To investigate the effects of combined deficiency of Tet1 and Tet2 on pluripotency and developm...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-42396 | biostudies-arrayexpress
UnknownDiesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis.
Not available
S-EPMC6703953 | biostudies-literature
Unknown2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
Not available
S-EPMC4663076 | biostudies-literature
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