Sort   by:  
 Page size 
TranscriptomicsThe histone demethylase JMJD1A is essential to prostate cancer cells through regulation of c-Myc expression
Analysis of gene expresssion altered upon knockdown of histone demethylase JMJD1A in human prostate cancer cells. The objective is to elucidate the transcriptional programs that are controlled by JMJD1A in human prostate cancer. CWR22Rv1 prostate cancer cells were transduced with lentiviral particle...
ORGANISM(S): Homo sapiens 
2015-09-08 | E-GEOD-70498 | biostudies-arrayexpress
TranscriptomicsNotch2 over expression in urinary bladder RT4V6 cell line
Notch2 in promotion of bladder cancer growth and metastasis through epithelial to mesenchymal transition (EMT), cell cycle progression and maintenance of stemness. Notch2 induced gene expression in human urinary bladder cancer was measured at three independent experiments.
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-60564 | biostudies-arrayexpress
TranscriptomicsPatient-derived primary xenografts in the preclinical development of novel targeted therapies for bladder cancer
Purpose: While molecular targeted therapy has revolutionized the treatment of many cancers, little progress has been made in the development of novel therapies for muscle invasive bladder cancer (MIBC). Here we report on the establishment and characterization of patient-derived primary MIBC xenograf...
ORGANISM(S): Mus musculus 
2015-03-27 | E-GEOD-67312 | biostudies-arrayexpress
TranscriptomicsThe E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity cancer.
The androgen receptor (AR) plays a central role in the development of castration resistant prostate cancer (CRPC). Here, we demonstrate that the ubiquitin ligase Siah2 targets a select pool of NCOR1-bound, transcriptionally inactive AR for ubiquitination dependent degradation, thereby promoting the ...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44319 | biostudies-arrayexpress
Sort   by:  
 Page size