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TranscriptomicsExtinction learning
Extinction learning refers to the phenomenon that a previously learned response to an environmental stimulus, for example the expression of an aversive behavior upon exposure to a specific context, is reduced when the stimulus is repeatedly presented in the absence of a previously paired aversive ev...
ORGANISM(S): Mus musculus 
2011-08-07 | E-GEOD-31063 | biostudies-arrayexpress
TranscriptomicsLincRNAs involved in DCS-induced fear extinction: Shedding light on the transcriptomic dark matter
There is a growing appreciation of the role of non-coding RNAs in the regulation of gene and protein expression. Long non-coding RNAs can modulate splicing by hybridizing with precursor messenger RNAs (pre-mRNAs) and influence RNA editing, mRNA stability, translation activation and microRNA-mRNA int...
ORGANISM(S): Rattus norvegicus 
2020-03-01 | E-MTAB-8647 | biostudies-arrayexpress
ProteomicsSelective dopamine transporter inhibition with CE-123 promotes fear extinction and remodels the basolateral amygdala proteome after fear conditioning in adolescent male rats
Persistent fear responses and impaired fear extinction are hallmark features of stress-related disorders. Dopaminergic signalling within amygdala-centred circuits contributes to these processes, yet the molecular mechanisms through which dopamine regulates fear extinction remain incompletely underst...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-10-05 | PXD075812 | Pride
Hippocampus Proteomics ce123 Basolateral amygdala Ptsd 
ProteomicsProteomic Insights into Extinction Memory Deficits in Stress-Susceptible Female Rats
Stress exposure can disrupt fear extinction, which is a hallmark of some stress-related disorders. The underlying molecular mechanisms of impaired extinction, especially in females, remain poorly understood. In this study, we investigated proteomics changes in the infralimbic cortex, a region critic...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD069169 | Pride
Tau protein Neurogranin Single prolonged stress Quantitative proteomics Fear extinction Infralimbic cortex Stress susceptibility 
GenomicsSynaptic and transcriptomic features of fear matrix pyramidal neurons predict inefficient fear extinction
Synaptic and transcriptomic features of fear matrix pyramidal neurons predict inefficient fear extinction
PRJNA861262 | ENA
GenomicsTranscriptomic architecture of weak versus strong fear extinction learning uncovers extinction-suppressive role of Tia1
Transcriptomic architecture of weak versus strong fear extinction learning uncovers extinction-suppressive role of Tia1
PRJNA1279021 | ENA
TranscriptomicsMicroarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning
Using Illumina MouseWG-6v2 microarrays, we investigated the gene transcription changes in microglia and peripheral monocytes after contextual fear conditioning of C57BL/6J mice. Mice were trained with or without a single minimized footshock stimulation (0-s or 2-s, 0.4 mA) and re-exposed to the trai...
ORGANISM(S): Mus musculus 
2022-10-28 | E-MTAB-12361 | biostudies-arrayexpress
TranscriptomicsSynaptic and transcriptomic features of fear matrix pyramidal neurons predict inefficient fear extinction
Trauma-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterized mouse phenotypes that spontaneously show individual differences in adaptive or maladaptive fear extinction and, before the traumatic experience, we found that speci...
ORGANISM(S): Mus musculus 
2023-06-02 | GSE209572 | GEO
GenomicsPhospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction
Phospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction
PRJNA1167232 | ENA
TranscriptomicsTranscriptomic architecture of weak versus strong fear extinction learning uncovers extinction-suppressive role of Tia1
BACKGROUND: Extinction, the capacity for an individual to inhibit or diminish maladaptive fear memories, is a critical aspect of fear processing. In humans, weak extinction learning is often observed in anxiety and fear-related disorders, such as PTSD. However, the mechanisms behind regulating extin...
ORGANISM(S): Mus musculus 
2025-12-02 | GSE300091 | GEO
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