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TranscriptomicsOviductal vs. ovarian epithelial transformation yields very different tumor phenotypes in Apc fl/fl;Pten fl/fl mice
We treated 6-8 week old mice that had floxed alleles of both Apc and Pten (for both alleles in each case) that also carry an Ovgp1-iCre-ERT2 transgene, with one of two treatments; a third group received neither treatment. The Ovgp1-iCre-ERT2 expresses Cre recombinase fused to a tamoxifen-inducible f...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-80085 | biostudies-arrayexpress
TranscriptomicsMicrosatellite stable (n=38) and instable-high (n=13) human colorectal tumors assayed with Affymetrix HuGeneFL arrays.
mRNA assays were performed on 51 samples of human colorectal tumors using Affymetrix HuGeneFL arrays containing 7129 probe-sets. We compared 38 microsatelite stable (MSS) tumors with 13 microsatellite instable-high (MSI) tumors to form a list of genes differing between the two types. In order to i...
ORGANISM(S): Homo sapiens 
2009-04-10 | E-GEOD-11543 | biostudies-arrayexpress
Genomicsena-DATASET-Genentech-07-04-2014-17:40:39:195-163 - samples
Alternative splicing plays critical roles in differentiation, development, and cancer (Pettigrew et al., 2008; Chen and Manley, 2009). The recent identification of specific spliceosome inhibitors has generated interest in the therapeutic potential of targeting this cellular process (van Alphen et al...
EGAD00001000817 | EGA
GenomicsRNAseq data to study PRPF6 regulated splice forms in colon cancer cell lines
Alternative splicing plays critical roles in differentiation, development, and cancer (Pettigrew et al., 2008; Chen and Manley, 2009). The recent identification of specific spliceosome inhibitors has generated interest in the therapeutic potential of targeting this cellular process (van Alphen et al...
EGAS00001000761 | EGA
TranscriptomicsEffects of Arid1a knockout in murine ovarian endometrioid carcinomas with biallelic inactivation of Apc and Pten
We mated mice with floxed alleles of both Apc and Pten, to mice with floxed alleles for Arid1a, to obtain female mice with both copies of all three genes floxed. At 7 to 8 weeks of age the right ovarian bursal cavites of the mice were injected with 50 million plaque-forming units of adenovirus expr...
ORGANISM(S): Mus musculus 
2015-08-04 | E-GEOD-67695 | biostudies-arrayexpress
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