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TranscriptomicsRNAseq of human epithelial lung carcinoma cell line A549 exposed to ceria, silver or zinc ions, micron-sized particles or nanoparticles
The toxicity of silver and zinc oxide nanoparticles is hypothesised to be mediated by dissolved metal ions and cerium dioxide nanoparticles (CeO2 NPs) are hypothesised to induce toxicity specifically by oxidative stress dependant on their surface redox state. To test these hypotheses, RNAseq was app...
ORGANISM(S): Homo sapiens 
2018-02-01 | E-MTAB-5734 | biostudies-arrayexpress
TranscriptomicsIn vivo RNA interference RNAi target sequencing of Trypanosoma brucei
A direct comparison of RNAi in vitro with RNAi in vivo is being performed using RNA interference (RNAi) target sequencing (RIT-Seq) of Trypanosoma brucei to identify all genes specifically required for growth in vivo (the infectome). Assembly of the bloodstream-form T. brucei RNAi library and the R...
ORGANISM(S): Trypanosoma brucei 
2014-01-21 | E-ERAD-110 | biostudies-arrayexpress
TranscriptomicsRNA-seq of blood samples from patients diagnosed with visceral leishmaniasis and asymptomatic individuals (Brazil)
To ascertain which genes are involved in the outcome of Leishmania infantum infection and immunopathology of human visceral leishmaniasis (VL), we investigated the transcriptional profile of whole blood samples from patients diagnosed with active VL compared to asymptomatic individuals (positive ser...
ORGANISM(S): Homo sapiens 
2020-08-06 | E-MTAB-8818 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of nascent and mature pancreatic beta cells
This experiment used RNA-Seq technology to examine transcription profile in FACS-sorted MIP-EGFP+ mouse pancreatic cells at E16.5 (nascent beta cells) and P60 (mature beta cells). Such an analysis should reveal the gene transcription alterations for beta cell development and for function.
ORGANISM(S): Mus musculus 
2015-10-01 | E-MTAB-3351 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of acinar cells from mice engineered with 3 TFs for reprogramming to beta cells
This experiment used RNA-Seq technology to explore gene expression in mouse FACS-purified pancreatic P60 Acinar cells, P60 Beta-cells, 1 day 3TF (MafA/Neurog3/Pdx1)-induced Acinar cells and 7 days 3TF-induced Acinar cells.ďż˝
ORGANISM(S): Mus musculus 
2016-07-06 | E-MTAB-3921 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the malaria parasite Plasmodium falciparum 3D7 during its intraerythrocytic development cycle
The parasite Plasmodium falciparum is responsible for severe malaria, which is still one of the major causes of death in developing countries. To provide a new RNA-seq reference dataset for its blood-stage transcriptome according to current guidelines and best practices, we performed a time course e...
ORGANISM(S): Plasmodium falciparum 3D7 
2019-07-02 | E-MTAB-7731 | biostudies-arrayexpress
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