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TranscriptomicsTranscription analysis of E. coli processed at persistent and decreasing glucose limitation in a fed-batch cultivation
A time series of whole-genome transcription profiling of E. coli K-12 W3110 was performed to study the dynamic physiological response of E. coli K-12 W3110 to limited carbon conditions. cDNA from eight time intervals after glucose limitation, representing different stages of glucose depletion, along...
ORGANISM(S): Escherichia coli W3110 
2010-05-19 | E-GEOD-10307 | biostudies-arrayexpress
TranscriptomicsTranscriptomic reprogramming of Ethanol adapted vs Ethanol non adapted culture
We have previously shown that fed-batch processes with the longest uncoupling phase (ethanol adapted) were characterized by induction of storage carbohydrates, a metabolic event typical of yeast cells experiencing nutrient limitation, at the onset of this phase, whereas this metabolic event was not ...
ORGANISM(S): Saccharomyces cerevisiae 
2009-08-31 | E-GEOD-15321 | biostudies-arrayexpress
TranscriptomicsYarrowia lipolytica fed-batch biolipid production.
Time-course transcriptomic profilling of the oleaginous yeast Yarrowia lipolytica, during a controlled fed-batch. A nitrogen limitation was applied during the course of the fed-batch to initiate de novo biolipid synthesis. Dual staining, one replicate per slide. On each slide, a time point sample an...
ORGANISM(S): Yarrowia lipolytica 
2011-05-15 | E-GEOD-29046 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome response of recombinant protein xylanase producing E. coli in high cell density fed batch culture
Strong production of recombinant proteins interfere with cellular processes in many ways. The extent of the bacterial stress response is determined by the specific properties of the recombinant protein, and by the rates of transcription and translation. The consideration of bacterial stress and star...
ORGANISM(S): Escherichia coli 
2011-05-23 | E-GEOD-29439 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of growth on methanol in a typical fed batch culture of Pichia pastoris
We have followed a typical fed-batch induction regime for heterologous protein production under the control of the AOX1 promoter using both microarray and metabolomic analysis. The genetic constructs involved 1 and 3 copies of the TRY1 gene, encoding human trypsinogen, In small-scale laboratory cult...
ORGANISM(S): Pichia pastoris 
2014-10-01 | E-MTAB-2530 | biostudies-arrayexpress
TranscriptomicsAnalyzing the metabolic stress response of recombinant Escherichia coli cultures expressing human interferon beta in high cell density fed batch cultures using time course transcriptomic data
Over expression of recombinant proteins is known to cause a metabolic burden to the host cells which leads to down regulation of both growth rates and protein expression. Most studies in this regard have been conducted in low density shake flask cultures which does not capture the essential features...
ORGANISM(S): Escherichia coli 
2011-04-06 | E-GEOD-28412 | biostudies-arrayexpress
MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
TranscriptomicsYarrowia lipolytica fed-batch biolipid production.
Time-course transcriptomic profilling of the oleaginous yeast Yarrowia lipolytica, during a controlled fed-batch. A nitrogen limitation was applied during the course of the fed-batch to initiate de novo biolipid synthesis.
ORGANISM(S): Yarrowia lipolytica 
2011-05-15 | GSE29046 | GEO
GenomicsTrickle Bed Reactor and Batch-Fed Metagenome
Metagenome of microbial community of samples from syngas trickle bed reactors and batch-fed samples
PRJNA1456936 | ENA
GenomicsIterative genome engineering of E. coli for fed-batch production of L-tyrosine.
Iterative genome engineering of E. coli for fed-batch production of L-tyrosine.
PRJNA1102680 | ENA
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