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ProteomicsTargeted MS assay to evaluate Cereblon neosubstrate changes in rabbit embryos following maternal administration of IMiDs
Targeted protein degradation is the selective removal of a protein of interest through hijacking intracellular protein cleanup machinery. This rapidly growing field currently relies heavily on the use of the E3 ligase Cereblon (CRBN) to target proteins for degradation, including the immunomodulatory...
ORGANISM(S): Oryctolagus Cuniculus 
PXD050568 | panorama
ProteomicsComplement activation by AAV-neutralizing antibody complexes
IP-MS analysis of AAV9 empty capsid protein-protein interactions with serum from healthy human donors.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-09 | MSV000091454 | MassIVE
ProteomicsTandem Mass Tag-Based Quantitative Proteomic Profiling Identifies Novel Serum Biomarkers of Drug-Induced Liver Injury in Humans
Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. In this study we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in a cohort of patients ...
ORGANISM(S): Homo Sapiens 
2024-01-04 | PXD034882 | panorama
ProteomicsHighly multiplexed kinase profiling in spleen with targeted mass spectrometry reveals kinome plasticity across species
Early attrition of drug candidates, including kinase inhibitors, often occurs due to issues that arise during preclinical safety and efficacy evaluation. This problem may be exacerbated by the fact that these studies might fail to consider the basic physiological differences which could exist betwee...
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus Canis Lupus Familiaris Macaca Fascicularis 
2021-08-19 | PXD024650 | panorama
ProteomicsDrug Induced Liver Injury Biomarker Discovery Data
Discovery proteomics was conducted on serum samples using tandem mass tagging for relative quantitation to discover potential new biomarkers of DILI.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-01 | MSV000089782 | MassIVE
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