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UnknownDetection of Genomically Aberrant Cells within Circulating Tumor Microemboli (CTMs) Isolated from Early-Stage Breast Cancer Patients.
Circulating tumor microemboli (CTMs) are clusters of cancer cells detached from solid tumors, whose study can reveal mechanisms underlying metastatization. As they frequently comprise unknown fractions of leukocytes, the analysis of copy number alterations (CNAs) is challenging. To address this, we ...
S-EPMC8003526 | biostudies-literature
UnknownPraja2 controls P-body assembly and translation in glioblastoma by non-proteolytic ubiquitination of DDX6
Glioblastoma multiforme (GBM) is the most lethal form of malignant brain tumor in adults. Dysregulation of protein synthesis contributes to cancer cell plasticity, driving GBM cell heterogeneity, metastatic behavior and drug resistance. Understanding the complex network and signaling pathways govern...
S-SCDT-10_1038-S44319-025-00425-5 | biostudies-other
UnknownThe TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation
The primary cilium is a microtubule-based sensory organelle that dynamically links signalling pathways to cell differentiation, growth, and development. Genetic defects of primary cilia are responsible for genetic disorders known as ciliopathies. Oro-facial digital type I syndrome (OFDI) is an X-lin...
S-SCDT-EMBOJ-2020-106503P | biostudies-other
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