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GenomicsTCC in pluripotent and differentiated cells
Regulation of gene expression underlies the establishment and maintenance of cell identity. Chromatin structure and gene activity are linked. Recently CTCF anchored loops have been described as major features of chromatin organisation. However, the dynamics and role for these structures in differ...
ORGANISM(S): Mus musculus 
2018-11-08 | E-MTAB-4870 | biostudies-arrayexpress
TranscriptomicsGain of chromatin loops marks the exit from naïve pluripotency – in-situ Hi-C data
In-situ Hi-C data for mouse embryonic stem cells (ES cells, grown in the presence of FBS and LIF) and for NS cells.
ORGANISM(S): Mus musculus 
2018-11-08 | E-MTAB-6591 | biostudies-arrayexpress
GenomicsDynamic alterations of 3D chromatin structure during differentiation
Regulation of gene expression underlies the establishment and maintenance of cell identity. Chromatin structure and gene activity are linked at long-range via positioning of loci to transcriptionally permissive (euchromatin) or repressive (heterochromatin) environments and at short-range by connecti...
ORGANISM(S): Mus musculus 
2019-08-27 | E-MTAB-2063 | biostudies-arrayexpress
UnknownBody Mass Index Thresholds and the Use of Bariatric Surgery in the Field of Kidney Transplantation in Germany.
Not available
S-EPMC8986752 | biostudies-literature
UnknownGenome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23.
Not available
S-EPMC8139853 | biostudies-literature
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [LS-174-T]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67846 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [Colo205]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67845 | biostudies-arrayexpress
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
UnknownStatus of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey.
Not available
S-EPMC12005017 | biostudies-literature
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