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MetabolomicsGlobal analysis of plasma lipidomics reveals altered lipid signatures in patients with osteonecrosis of the femoral head

AIMS: Although studies have made the connection between lipid metabolism disorder and osteonecrosis of the femoral head (ONFH), the characteristics of the circulating lipidome signature of ONFH have not yet been investigated yet and need to be explored.

METHODS:

2021-07-06 | MTBLS2262 | MetaboLights
TranscriptomicsMicroarray gene profiling in glucocorticoid-induced Avascular Necrosis of the Femoral Head in a Rat Model
Wistar Kyoto Rats were administered glucocorticoid pellets and placebo pellets for 6 months. After 6 months rats were sacrificed and their femoral heads were histologically examined for the detection of avascular necrosis of the femoral head. Total RNA was extracted from femoral heads and submitted ...
ORGANISM(S): Rattus norvegicus 
2011-06-09 | E-MEXP-2751 | biostudies-arrayexpress
ProteomicsChicken plasma proteome femoral head seperation
Lameness due to femoral head separation (FHS) is a production and welfare issue in commercial poultry. FHS is an idiopathic disorder, which is attributed to a myriad of factors but in order to improve bone health, broiler breeders must be prognosed for disease susceptibility and selected against FHS...
ORGANISM(S): Gallus gallus (Chicken) 
2016-08-09 | PXD003292 | Pride
Chicken Proteomics Plasma Femoral head necrosis Biomarkers 
ProteomicsIntegrated Proteomics and Metabolomics Analysis of Sclerosis-Related Proteins and Femoral Head Necrosis Following Internal Fixation of Femoral Neck Fractures-1
Femoral head necrosis (FHN) is a serious complication after femoral neck fractures (FNF), often linked to sclerosis around screw paths. Our study aimed to uncover the proteomic and metabolomic underpinnings of FHN and sclerosis using integrated proteomics and metabolomics analysis. We quantitatively...
ORGANISM(S): Homo Sapiens 
2024-04-27 | PXD051808 |
ProteomicsProteomics analysis of hip articular cartilage identifies differentially expressed proteins associated with osteonecrosis of the femoral head
The cartilage degeneration that accompanies subchondral bone necrosis plays an important role in the development of osteonecrosis of femoral head (ONFH). To better understand the molecular basis of cartilage degradation in ONFH, we compared the proteomics profile of ONFH cartilage with that of norma...
ORGANISM(S): Homo Sapiens 
2021-01-20 | PXD023698 |
TranscriptomicsGene expression profiling of hip cartilage with necrosis of femoral head
The pathogenesis of necrosis of femoral head (NFH) remains elusive now. Limited studies were conducted to investigate the molecular mechanism of hip articular cartilage damage of NFH. We conducted a genome-wide gene expression profiling of hip articular cartilage with NFH. Hip articular cartilage sp...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-74089 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of hip cartilage with necrosis of femoral head
The pathogenesis of necrosis of femoral head (NFH) remains elusive now. Limited studies were conducted to investigate the molecular mechanism of hip articular cartilage damage of NFH. We conducted a genome-wide gene expression profiling of hip articular cartilage with NFH.
ORGANISM(S): Homo sapiens 
2016-06-01 | GSE74089 | GEO
TranscriptomicsExpression data from normal rat and steroid induced necrosis of femoral head rat
The steriod-induced necrosis of femoral head(SINFH) is a serious clinical problem and the underlying mechanism of this disease remains unknown. As its etiology and pathogenesis are not clear, there hasn’t been an effective treatment yet. In-depth studies on its pathogenesis will provide important in...
ORGANISM(S): Rattus norvegicus 
2010-12-28 | E-GEOD-26316 | biostudies-arrayexpress
TranscriptomicsOsteogenesis-Related Long Noncoding RNA GAS5 as a Novel Biomarker for Osteonecrosis of Femoral Head
Subchondral bone samples from six patients who underwent primary total hip arthroplasty (three ONFH patients and three patients in control group with femoral neck fracture) were obtained.
ORGANISM(S): Homo sapiens 
2022-03-12 | E-MTAB-11493 | biostudies-arrayexpress
GenomicsStaphylococcus
Staphylococcus aureus from femoral head necrosis Genome sequencing and assembly
PRJNA554662 | ENA
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