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MetabolomicsTherapeutic effects of traditional Chinese medicine compound Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota

Hua-Feng-Dan is a traditional Chinese medicine compound used to treat ischemic stroke, but little is known about its therapeutic mechanism. This study explored whether and how the mechanism involves readjustment of gut microbiota. Rats were subjected to middle cerebral artery occlusion as a model...

2025-01-06 | MTBLS10818 | MetaboLights
MetabolomicsL-serine enables reducing the virulence of Acinetobacter baumannii and modulating the SIRT1 pathway to eliminate the pathogen

The emergence of high-virulent Acinetobacter baumannii strains increases the mortality of patients and seriously affects their prognosis, which motivates us to explore novel ways to control such infections. In this study, gas chromatography-mass spectrometry was adopted to explore the me...

2024-01-18 | MTBLS8966 | MetaboLights
Transcriptomics3C-seq of HT29 cells with CCAT1-L knockdown or scramble knockdown
CCAT1-L is a highly expressed long noncoding RNA located in the colorectal cancer specific super enhance region about 500 kb upstream of MYC gene. Knockdown of CCAT1-L significantly down-regulated interaction frequency between CCAT1 and MYC locus and repress MYC expression, suggesting a long-range c...
ORGANISM(S): Homo sapiens 
2014-02-22 | E-GEOD-55261 | biostudies-arrayexpress
ProteomicsSelective Permeability of Mouse Blood-Aqueous Barrier as Determined by 15N-Heavy Isotope Tracing and Mass Spectrometry
Pan Liu , Benjamin R. Thomson , Natalia Khalatyan , Liang Feng , Xiaorong Liu , Jeffrey N Savas , Susan E. Quaggin , Jing Jin
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-07-10 | MSV000082590 | MassIVE
UnknownMethodological and reporting quality evaluation of meta-analyses on the Chinese herbal preparation Zheng Qing Feng Tong Ning for the treatment of rheumatoid arthritis.
Not available
S-EPMC7318442 | biostudies-literature
TranscriptomicsSaccharomyces cerevisiae: DSB mapping by Break-chip in a two-color experiment (G1 control vs. S phase samples)
Break-chip (microarray-based double strand break mapping) analysis of mec1 cells recovering from 200 mM hydroxyurea in the presence or absence of 0.8 micromolar bathophenanthroline sulfonate (BPS). We asked if the presence of an iron chelator, BPS, during cell recovery from transient exposure to 200...
ORGANISM(S): Saccharomyces cerevisiae 
2015-01-12 | E-GEOD-64446 | biostudies-arrayexpress
UnknownYu-Ping-Feng-San improve the immunosuppression of microenvironment in hepatocellular carcinoma by promoting the maturation of DCs through the JAK2-STAT3 pathway.
Not available
S-EPMC11682348 | biostudies-literature
TranscriptomicsRNA-seq from paired human CRC/control mucosa samples
We have used RNA-seq to examine gene expression from paired human CRC/control mucosa samples and identified CRC-specific expressed long noncoding RNAs To identify CRC-specific expressed genes, including long noncoding RNAs
ORGANISM(S): Homo sapiens 
2014-02-22 | E-GEOD-55259 | biostudies-arrayexpress
UnknownPolycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin.
Not available
S-EPMC2581563 | biostudies-literature
MetabolomicsTranscriptomics and metabolomics of engineered Synechococcus elongatus during photomixotrophic growth

BACKGROUND: Converting carbon dioxide (CO2) into value-added chemicals using engineered cyanobacteria is a promising strategy to tackle the global warming and energy shortage issues. However, most cyanobacteria are autotrophic and use CO2 as a sole carbon source, which makes it h...

2022-03-21 | MTBLS2825 | MetaboLights
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