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ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of a Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared with the wild-type ...
ORGANISM(S): Plasmodium berghei ANKA 
2025-06-27 | PXD053412 | Pride
Plasmodium  ser/thr protein phosphatase 6  gametogenesis  ca2+ signaling cascade  pkg 
ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared to wild-type P. b...
ORGANISM(S): Plasmodium berghei 
2025-06-27 | PXD063164 | Pride
Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite plasmodium berghei 
ProteomicsLC-MS/MS-based metabolomics and proteomics reveal the intervention of Kangnian Decoction on the postoperative intestinal adhesion of rats
This study aims to explore the therapeutic effects of KN decoction in a PIA rat model, as well as its potential mechanisms via metabolomics and proteomics analyses.
ORGANISM(S): Rattus Norvegicus 
PXD055723 |
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
PXD053334 |
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