Fer tyrosine kinase

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Metabolite Name

Spermidine (3)
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First Public Date

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Release Date

2010 (95)
2013 (89)
2012 (78)
2014 (68)
2015 (65)
2011 (63)
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2008 (48)
2009 (42)
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Lab affiliation

Drug Discovery Moffitt Cancer Center Tampa, FL, USA (2)
Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine (1)
Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS) School of Life Science Technical University Munich (TUM) Gregor-Mendel-Straße 4 85354 Freising GERMANY (1)
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands (1)

Tags

xref:PubMed:41115375 (1)
xref:PubMed:37329887 (1)

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FER drives tumor progression cues of invasive breast cancer cells through kinase-dependent control of proliferation and endosomal recycling

Triple-Negative Breast Cancer (TNBC) is a poorly targetable cancer subtype that exhibits a high metastatic potential. To develop new intervention strategies, it is crucial to understand the mechanisms governing migratory and invasive features of TNBC cells. Previously it was shown that high expressi...

ORGANISM(S): Homo sapiens (Human)

2022-04-15 | PXD021307 | Pride

FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer

Tyrosine phosphorylation, orchestrated by tyrosine kinases and phosphatases, modulates a multi-layered signaling network in a time and space dependent manner. Dysregulation of this post-translational modification is inevitably associated with pathological diseases. Our previous work has demonstrated...

ORGANISM(S): Homo Sapiens

2020-10-19 | PXD022084 |

FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB.

Not available

S-EPMC3093511 | biostudies-literature

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.

Not available

S-EPMC6511961 | biostudies-literature

Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin.

Not available

S-EPMC2592841 | biostudies-literature

Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells.