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TranscriptomicsIntegrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
We have found that thyroid hormones (THs), acting as soluble integrin αvβ3 ligands, activate growth-related signaling pathways in T-cell lymphomas (TCL). Specifically, TH-activated αvβ3 integrin signaling promotes TCL proliferation and angiogenesis, in part, via the up-regulation of VEGF. CUTLL1 cel...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-63122 | biostudies-arrayexpress
TranscriptomicsCombinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphoma
Aggressive double and triple hit (DH/TH) DLBCL feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls post-transcriptional dynamics of key mRNA species including those encoding BCL6, MYC and BCL2. Using a proteomics approach, we found that Hsp90 binds to and maintains acti...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-63265 | biostudies-arrayexpress
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