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TranscriptomicsCooperation between ASTER-dependent nonvesicular transport and NPC1L1 facilitates dietary cholesterol uptake
Intestinal cholesterol absorption is an important determinant of systemic cholesterol homeostasis. Niemann-Pick C1 Like 1 (NPC1L1), the target of the drug ezetimibe, is a critical player in dietary cholesterol uptake. But how cholesterol moves within the cell downstream of NPC1L1 is unknown. Here we...
ORGANISM(S): Mus musculus 
2023-12-21 | GSE206780 | GEO
Transcriptomics4f-SAMMY-seq (Sequential Analysis of MacroMolecules Accessibility) and total RNA-seq data from prostate biopsies of 25 chemo-naïve patients (7 healthy biopsies and 18 tumor biopsies)
We used a groundbreaking epigenomic profiling technique developed in our laboratory, the 4f-SAMMY-seq, along with RNA-seq on 7 healthy biopsies and 18 prostate tumor biopsies. Our study represents the first direct examination of chromatin organization in patient-derived prostate biopsies. Leveraging...
ORGANISM(S): Homo sapiens 
2025-08-21 | E-MTAB-14226 | biostudies-arrayexpress
TranscriptomicsMaintenance of Leukemic Cell Identity by the Activity of the Polycomb Complex PRC1 (RNA-seq)
These data include RNA Seq data generated from Ring1b wild type and Ring1b KO Ring1a-/- Cdkn2a-/- Lin- HSC cells non-transduced or transduced with MLL-AF9, HOXA9 and PML-RARa. Total RNA extracted from Ring1b wild type and Ring1b KO Ring1a-/- Cdkn2a-/- Lin- HSC cells non-transduced or transduced wit...
ORGANISM(S): Mus musculus 
2016-10-21 | E-GEOD-67517 | biostudies-arrayexpress
GenomicsMaintenance of Leukemic Cell Identity by the Activity of the Polycomb Complex PRC1 (ChIP-seq)
These data include the genome wide occupancy of H2AUbq by ChIP sequencing in Cdkn2a-/- Lin- HSC cells non-transduced or transduced with MLL-AF9, HOXA9 and PML-RARa. Immuno-precipitation of formaldehyde cross-linked chromatin prepared from Cdkn2a-/- Lin- HSC cells non-transduced or transduced with ML...
ORGANISM(S): Mus musculus 
2016-10-21 | E-GEOD-67498 | biostudies-arrayexpress
GenomicsCooperation between ASTER-dependent nonvesicular transport and NPC1L1 facilitates dietary cholesterol uptake
Cooperation between ASTER-dependent nonvesicular transport and NPC1L1 facilitates dietary cholesterol uptake
PRJNA852178 | ENA
ProteomicsCholesterol binding to VCAM-1 promotes vascular inflammation
Hypercholesterolemia has long been implicated in endothelial cell (EC) dysfunction, but the mechanisms by which excess cholesterol causes vascular pathology are incompletely understood. Here we used a cholesterol-mimetic probe to map cholesterol-protein interactions in primary human ECs and discover...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000099325 | MassIVE
TranscriptomicsSingle-cell RNA-seq of hESC (H9) lines exposed to a striatal differentiation protocol
Use of single-cell transcriptomics to measure how well medium spiny projection neurons, derived from human ESC, recapitulate human striatal development in vivo. This in vitro single-cell dataset was derived after exposing hESC lines (H9) to a novel striatal differentiation protocol and performing si...
ORGANISM(S): Homo sapiens 
2023-01-31 | E-MTAB-12080 | biostudies-arrayexpress
MetabolomicsIntracellular iron overload rewires HSC metabolism by impairing mitochondrial fitness
Iron is an essential element for several cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). When in excess it reduces quiescence and self-renewal, however, whether and how iron influences HSC metabolism is still unknown. Here, w...
2024-12-04 | MTBLS11778 | MetaboLights
UnknownMulticentric, observational, longitudinal study for the evaluation of nutritional management implications in newly diagnosed Italian cancer patients: the Italian Registry of Malnutrition in Oncology (IRMO).
Not available
S-EPMC10445343 | biostudies-literature
UnknownKDM6A Loss Enhances Oxidative Phosphorylation Uncovering Tissue-Level Convergent Evolution
Not available
S-SCDT-10_1038-S44318-026-00891-0 | biostudies-other
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