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TranscriptomicsExpression data from untreated and ATP treated AML blasts
In the present study, we investigated whether, and to what extent, P2Rs and their ligands are involved in the regulation of AML cells. Our findings show that AML blasts express several receptors belonging to the P2X and P2Y family. Although different samples respond differently to ATP and UTP stimul...
ORGANISM(S): Homo sapiens 
2012-02-25 | E-GEOD-30903 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+ cells and treatment with UTP and CXCL12
Homing and engraftment of hematopoietic stem cells (HSCs) to the bone marrow (BM) involve a complex interplay between chemokines, cytokines, and non-peptide molecules. Extracellular nucleotides and their cognate P2 receptors are emerging as key-factors of inflammation and related chemotactic respons...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5168 | biostudies-arrayexpress
TranscriptomicshMSC ATP treatment
Nucleotides triphosphates are extracellular messengers binding to specific plasma membrane receptors (P2Rs) that modulate responses as different as proliferation, differentiation, migration or cell death on several cell types including hematopoietic stem cells. Little and controversial information i...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-14566 | biostudies-arrayexpress
TranscriptomicsExtracellular purines promote the differentiation capacity of human bone marrow-derived mesenchymal stem cells
Extracellular nucleotides are potent signaling molecules mediating cell-specific biological functions. We previously demonstrated that adenosine 5'-triphosphate (ATP) inhibits the proliferation while stimulating the migration, in vitro and in vivo, of human bone marrow-derived mesenchymal stem cells...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-37237 | biostudies-arrayexpress
UnknownTargeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies.
Not available
S-EPMC6470723 | biostudies-literature
UnknownKDM6A Loss Enhances Oxidative Phosphorylation Uncovering Tissue-Level Convergent Evolution
Not available
S-SCDT-10_1038-S44318-026-00891-0 | biostudies-other
MetabolomicsIntracellular iron overload rewires HSC metabolism by impairing mitochondrial fitness
Iron is an essential element for several cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). When in excess it reduces quiescence and self-renewal, however, whether and how iron influences HSC metabolism is still unknown. Here, w...
2024-12-04 | MTBLS11778 | MetaboLights
UnknownEffect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial.
Not available
S-EPMC10092300 | biostudies-literature
UnknownPancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries.
Not available
S-EPMC10771125 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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