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UnknownMutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Gain-of-function mutations in with no lysine (K) 1 (WNK1) and WNK4 genes are responsible for familial hyperkalemic hypertension (FHHt), a rare, inherited disorder characterized by arterial hypertension and hyperkalemia with metabolic acidosis. More recently, FHHt-causing mutations in the Kelch-like ...
S-EPMC7685730 | biostudies-literature
UnknownProteome-Wide Analysis of Cysteine S-Sulfenylation Using a Benzothiazine-Based Probe.
Oxidation of a protein cysteinyl thiol (Cys-SH) to S-sulfenic acid (Cys-SOH) by a reactive oxygen species (e.g., hydrogen peroxide), which is termed protein S-sulfenylation, is a reversible post-translational modification that plays a crucial role in redox regulation of protein function in various b...
S-EPMC6342663 | biostudies-literature
UnknownMining for protein S-sulfenylation in Arabidopsis uncovers redox-sensitive sites.
Hydrogen peroxide (H2O2) is an important messenger molecule for diverse cellular processes. H2O2 oxidizes proteinaceous cysteinyl thiols to sulfenic acid, also known as S-sulfenylation, thereby affecting the protein conformation and functionality. Although...
S-EPMC6800386 | biostudies-literature
ProteomicsMining for protein S-sulfenylation in Arabidopsis uncovers redox-sensitive sites
Hydrogen peroxide (H2O2) is an important messenger molecule for diverse cellular processes. H2O2 oxidizes proteinaceous cysteinyl thiols to sulfenic acid, also known as S-sulfenylation, thereby affecting the protein conformation and functionality. Although many proteins have been identified as S-sul...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-09-16 | PXD013495 | Pride
Chemoproteomics Btd Sulfenic acid 
ProteomicsProtein S-sulfenylation Arabidopsis - AtMAPK4
Study the oxidation-sensitivity of recombinant AtMAPK4 by treatment with 0 mM hydrogen peroxide (H2O2) (sample '_01'), 1 mM (sample '_02'), and 10 mM (sample '_03'). Each sample subdivided for trypsin and chymotrypsin digestion.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-09-16 | PXD013588 | Pride
Arabidopsis thaliana Mitogen-activated protein kinase S-sulfenylation Atmapk4 Mpk4 Cysteine oxidation 
UnknownSequence data and association statistics from 12,940 type 2 diabetes cases and controls.
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural var...
S-EPMC5735917 | biostudies-literature
UnknownComparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry.

Background and purpose

Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF).

Me...

S-EPMC9054878 | biostudies-literature
UnknownEffect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes.

Background

The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. We aimed to assess the safety and outcomes of revascularization treatments in patients with AI...
S-EPMC10734790 | biostudies-literature
UnknownStreptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2.
BackgroundAlthough recent epidemiological data suggest that pneumococci may contribute to the risk of SARS-CoV-2 disease, cases of coinfection with Streptococcus pneumoniae in patients with coronavirus disease 2019 (COVID-19) during hospitalization have been reported infrequently. This apparent cont...
S-EPMC8970672 | biostudies-literature
UnknownRisk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

Background

The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed...
S-EPMC6306365 | biostudies-literature
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