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TranscriptomicsGene expression profiles in semi-continuous culture with high-cell density under normal and low temperature conditions for scFv-Fc-producer CHO cells harboring an artificial promoter system with transcriptional positive-feedback loop of transactivator
We developed an artificial gene expression system with transcriptional positive-feedback loop of transactivator to induce the high expression of target genes in CHO cells. DNA microarray analysis was conducted in semi-continuous culture with high-cell-density culture under normal and low temperature...
ORGANISM(S): Cricetulus griseus 
2024-01-01 | E-MTAB-13440 | biostudies-arrayexpress
ProteomicsFood vacuole proteome of P. berghei heme pathway ferrochelatase knockout parasite by LC-MS/MS
LC-MS/MS of in-solution trypsin digested FV protein extracts was carried out for the FVs isolated from PbWT and PbFCKO parasites. The FV preparations had signature FV proteins such as plasmepsin IV, berghepain, aminopeptidases, subunits of vacuolar-type H+ATPase (V-type H ATPase), together with para...
ORGANISM(S): Plasmodium Plasmodium berghei ANKA 
2022-05-10 | PXD031736 | Pride
Knockout (ko) Food vacuole (fv) Wildtype (wt) Plasmodium berghei (pb) Ferrochelatase (fc) 
ProteomicsAssessment of host hemoglobin accumulation in P. berghei heme pathway ferrochelatase knockout parasite food vacuole by iTRAQ
Two independent sets of fourplex iTRAQ labelling were carried out to assess the accumulation of host Hb in PbFCKO FVs. The results obtained have suggested that there is a ~3-4 -fold increase in Hb and chains in FCKO FVs as quantified by iTRAQ.
ORGANISM(S): Plasmodium Plasmodium berghei ANKA 
2022-05-10 | PXD031738 | Pride
Knockout (ko) Food vacuole (fv) Hemoglobin (hb) Wildtype (wt) Plasmodium berghei (pb) Ferrochelatase (fc) 
UnknownThe heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target.
Not available
S-EPMC2703803 | biostudies-literature
UnknownMalaria parasite-synthesized heme is essential in the mosquito and liver stages and complements host heme in the blood stages of infection.
Not available
S-EPMC3731253 | biostudies-literature
TranscriptomicsIdentification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans
The identification of novel transcription factors associated to antifungal response may allow the discovery of fungal specific targets for new therapeutic strategies. A collection of 241 C. albicans transcriptional regulators mutants was screened for altered susceptibility to fluconazole, caspofungi...
ORGANISM(S): Candida albicans 
2012-05-02 | E-GEOD-37682 | biostudies-arrayexpress
TranscriptomicsExpression data from Arabidopsis during de-etiolation
Arabidopsis fc2-1 mutants fail to properly de-etiolate after a prolonged period in the dark. Our goal was to monitor whole genome expression during the first 2 hours of de-etiolation to determine the cuase of this growth arrest. In comparison with other mutants that also affect de-etiolation, we ide...
ORGANISM(S): Arabidopsis thaliana 
2015-08-06 | E-GEOD-71764 | biostudies-arrayexpress
TranscriptomicsMulti-level omics analysis of dystrophin loss and therapeutic restoration in a murine model [microRNA]
Duchenne muscular dystrophy (DMD) is a classical monogenic disorder, a model disease for genomic studies and a priority candidate for regenerative medicine and gene therapy. Although the genetic cause of DMD is well known, the molecular pathogenesis of disease and the response to therapy are incompl...
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-64419 | biostudies-arrayexpress
TranscriptomicsMulti-level omics analysis of dystrophin loss and therapeutic restoration in a murine model
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-64420 | biostudies-arrayexpress
TranscriptomicsComparison of systematic sequencing errors using spike-in standards
While the importance of random sequencing errors decreases at higher DNA or RNA sequencing depths, systematic sequencing errors (SSEs) dominate at high sequencing depths and can be difficult to distinguish from biological variants. These SSEs can cause base quality scores to underestimate the proba...
ORGANISM(S): Homo sapiens 
2012-03-03 | E-GEOD-36217 | biostudies-arrayexpress
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