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ProteomicsProteomics of Human Skeletal Muscle
The skeletal muscle proteomics study of vastus lateralis muscle biopsies which were collected from participants from the Genetic and Epigenetic Study of Aging and Laboratory Testing (GESTALT). The participants were free of major diseases, except for controlled hypertension or a history of cancer tha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096122 | MassIVE
ProteomicsAge-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy
To gain understanding on the mechanisms that drive immunosenescence in humans, we examined CD4+ T cells obtained from younger (20-39 years-old) and older (70+ years-old) healthy participants of the Baltimore Longitudinal Study on Aging (BLSA). We found that mitochondrial proteins involved in the el...
ORGANISM(S): Homo sapiens (Human) 
2019-11-27 | PXD016039 | Pride
Autophagy Proteomics Mitochondria Cd4+ t cells Aging 
ProteomicsProteomics of Human Skeletal Muscle
The skeletal muscle proteomics study of vastus lateralis muscle biopsies which were collected from participants from the Genetic and Epigenetic Study of Aging and Laboratory Testing (GESTALT). The participants were free of major diseases, except for controlled hypertension or a history of cancer tha...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD011967 | Pride
Proteomics Skeletal muscle 
ProteomicsSkeletal Muscle Proteomics of High Functioning Octogenarians
Skeletal muscle mass and function decline more precipitously after the age 75 y. To provide insights into biologically relevant mechanisms for preserving muscle mass and physical function in advanced age, a battery of physical function tests, muscle cross-sectional area by MRI and a vastus lateralis...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086195 | MassIVE
GenomicsNHLBI Family Heart Study (FamHS-Visit1 and FamHS-Visit2)

The Family Heart Study (FamHS) was funded by the National Heart, Lung, and Blood Institute (NHLBI). It was begun in 1992 with the ascertainment of 1,200 families, half randomly sampled, and half selected because of an excess of coronary heart disease (CHD) or risk factor abnormalities as compared...

phs000221.v1.p1 | EGA
UnknownModulation of innate immunity related genes resulting in prophylactic antimicrobial and antiviral properties.
Not available
S-EPMC11184722 | biostudies-literature
TranscriptomicsResveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on a high-fat, high-sugar diet.
Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and ...
ORGANISM(S): Macaca mulatta 
2014-04-21 | E-GEOD-50005 | biostudies-arrayexpress
TranscriptomicsAbundant Quantitative Trait Loci for CpG Methylation and Expression Across Human Brain Tissues
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We describe a set of integrated experiments designed to investigate the effects of common genetic variability on DNA methylation, mRNA...
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-15745 | biostudies-arrayexpress
UnknownTemporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio. Results from InCHIANTI follow-up study.
Not available
S-EPMC10350238 | biostudies-literature
UnknownMuscle quality, physical performance, and comorbidity are predicted by circulating procollagen type III N-terminal peptide (P3NP): the InCHIANTI follow-up study.
Not available
S-EPMC10828316 | biostudies-literature
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