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MetabolomicsSexual dimorphism in the fetal cardiac response to maternal nutrient restriction
Poor maternal nutrition causes intrauterine growth restriction (IUGR); however, its effects on fetal cardiac development are unclear. We have developed a baboon model of moderate maternal undernutrition, leading to IUGR. We hypothesized that the IUGR affects fetal cardiac structure and metabolism. S...
2018-04-30 | MTBLS426 | MetaboLights
MetabolomicsSingle-cell RNA sequencing decipher hepatic injury and APOA4 as a biomarker in males with intrauterine growth restriction

Intrauterine growth restriction (IUGR) is associated with increased relative liver weight at birth, hepatic function decline and a higher risk for chronic liver and cardiovascular diseases in adults. Precise mechanisms of early developmental plasticity to intervene in poor fetal programming and a...

2023-09-25 | MTBLS6881 | MetaboLights
MetabolomicsEffect of Genetically Reduced Maternal Myostatin on Late Gestation Maternal, Fetal, and Placental Metabolomes in Mice.
Myostatin (gene symbol: Mstn) is an autocrine and paracrine inhibitor of muscle growth. Pregnant mice with genetically reduced levels of myostatin give birth to offspring with greater adult muscle mass and bone biomechanical strength. However, maternal myostatin is not detectable in fetal cir...
2023-06-08 | MTBLS3345 | MetaboLights
Proteomicsfetal growth restriction_pancreas_differences in nutritional condition
Quantification of proteins in the pancreas of fetal growth restriction.
ORGANISM(S): Rattus Rattus (black Rat) 
PXD026502 | JPOST Repository
MetabolomicsExploratory research on first and second trimester urinary metabolic profiles and fetal growth restriction
Not available
ORGANISM(S): Homo sapiens 
ST000573 | MetabolomicsWorkbench
ProteomicsPROTEOMIC ANALYSIS OF THE UMBILICAL CORD IN FETAL GROWTH RESTRICTION AND PREECLAMPSIA
Fetal growth restriction (FGR) is associated with adverse perinatal outcomes. Pre-eclampsia (PreE) increases the associated perinatal morbidity and mortality. The structure of the umbilical cord in the setting of FGR and PreE has yet to be determined. This study aimed to examine chan...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-15 | MSV000087051 | MassIVE
MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
TranscriptomicsRegulation of Fetal Liver Growth in a Model of Diet Restriction in the Pregnant Rat
The present study was designed to test the hypothesis that limited growth of the fetal liver in the model of maternal fasting is independent of well-characterized signaling mechanisms that are known to regulate somatic growth in adult animals. We profiled the fetal hepatic transcriptome and translat...
ORGANISM(S): Rattus norvegicus 
2016-07-18 | E-GEOD-77112 | biostudies-arrayexpress
TranscriptomicsPostnatal Growth Restriction and Gene Expression Changes in a Mouse Model of Fetal Alcohol Syndrome
This SuperSeries is composed of the following subset Series: GSE23105: Postnatal Growth Restriction and Gene Expression Changes in a Mouse Model of Fetal Alcohol Syndrome (Kidney) GSE23106: Postnatal Growth Restriction and Gene Expression Changes in a Mouse Model of Fetal Alcohol Syndrome (Liver) Re...
ORGANISM(S): Mus musculus 
2010-09-30 | E-GEOD-23115 | biostudies-arrayexpress
TranscriptomicsPostnatal Growth Restriction and Gene Expression Changes in a Mouse Model of Fetal Alcohol Syndrome (Kidney)
Growth restriction, craniofacial dysmorphology and central nervous system defects are the main diagnostic features of fetal alcohol syndrome. Studies in humans and mice have reported that the growth restriction can be prenatal and/or postnatal, but the underlying mechanisms remain unknown. We recen...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-23105 | biostudies-arrayexpress
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