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ProteomicsA mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides
Less than half of all MS/MS spectra acquired in shotgun proteomics typically result in a confident peptide match. Here we present an ultra-tolerant Sequest database search that allowed peptide matching even with modifications of unknown masses up to ±500 Da. From an HEK293 cell proteome-wide datas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-06-19 | MSV000079841 | MassIVE
UnknownQuantifying dispersal between two colonies of northern elephant seals across 17 birth cohorts.
Not available
S-EPMC10688689 | biostudies-literature
TranscriptomicsThe fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
Background/Objectives: Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many sm...
ORGANISM(S): Homo sapiens 
2015-05-06 | E-GEOD-58622 | biostudies-arrayexpress
TranscriptomicsThe effect of dietary CLA on mammary tumorigenesis
Conjugated linoleic acid (CLA), a class of fatty acids found in beef and dairy products, has been shown to inhibit tumorigenesis in a variety of cancer model systems. Based on previously well-documented anti-tumor activity of CLA in rodent models of breast cancer, a pilot study was initiated to exam...
ORGANISM(S): Mus musculus 
2008-11-18 | E-GEOD-13553 | biostudies-arrayexpress
UnknownRandomized Phase III Noninferiority Study Comparing Two Radiotherapy Fractionation Schedules in Patients With Low-Risk Prostate Cancer.
Not available
S-EPMC4981980 | biostudies-literature
TranscriptomicsGain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome [camb1Mb data]
For many oncogenes, increased expression resulting from copy number gain confers a selective advantage to cells that consequently make up the tumour bulk. To identify oncogenes of potential biological significance in cervical squamous cell carcinoma (SCC), 36 primary samples and ten cell lines were ...
ORGANISM(S): Homo sapiens 
2011-02-16 | E-GEOD-27332 | biostudies-arrayexpress
TranscriptomicsGain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome [penn1Mb data]
For many oncogenes, increased expression resulting from copy number gain confers a selective advantage to cells that consequently make up the tumour bulk. To identify oncogenes of potential biological significance in cervical squamous cell carcinoma (SCC), 36 primary samples and ten cell lines were ...
ORGANISM(S): Homo sapiens 
2011-02-16 | E-GEOD-27331 | biostudies-arrayexpress
UnknownOne-year safety and efficacy study of arformoterol tartrate in patients with moderate to severe COPD.
Not available
S-EPMC4251615 | biostudies-literature
Genomicsc-Myc Transcriptionally Amplifies Sox2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells [ChIP-Seq]
An immortalized multipotent otic progenitor (iMOP) cell was generated by transient expression of c-Myc in Sox2-expressing otic progenitor cells. The procedure activated endogenous c-Myc expression in the cells and amplified existing Sox2-dependent transcripts to promote self-renewal. Downregulation ...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-62513 | biostudies-arrayexpress
TranscriptomicsmiRNA expression of human cancer and mouse cell lines
miRNA expression profile Keywords: small RNA profiling by high throughput sequencing The small RNA fraction (18-30nt) was cloned and sequenced from total RNA of each cell line
ORGANISM(S): Homo sapiens 
2009-08-24 | E-GEOD-16579 | biostudies-arrayexpress
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