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MetabolomicsThe Role of Intestinal-derived FGF15 and Vertical Sleeve Gastrectomy on Plasma Bile Acid Composition in Mice
Not available
ORGANISM(S): Mus musculus 
ST001743 | MetabolomicsWorkbench
TranscriptomicsEffect of FGF15 or FGF19 on mouse liver
Mouse FGF15 and human FGF19 are orthologous proteins that regulate bile acid metabolism. However, other hepatic functions of FGF15/19 are not well characterized. We used microarrays to analyze global hepatic gene expression in mice administered FGF15 or FGF19. Total liver RNA was isolated from wild...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-29426 | biostudies-arrayexpress
GenomicsFeeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut
Feeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut
PRJNA810868 | ENA
TranscriptomicsEffect of FGF15 or FGF19 on mouse liver
Mouse FGF15 and human FGF19 are orthologous proteins that regulate bile acid metabolism. However, other hepatic functions of FGF15/19 are not well characterized.
ORGANISM(S): Mus musculus 
2011-06-07 | GSE29426 | GEO
GenomicsFeeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut
Lysosome-mediated macroautophagy, including lipophagy, is activated under nutrient deprivation but is repressed after feeding. We show that feeding unexpectedly activates intestinal lipophagy in a manner dependent on both the orphan nuclear receptor, small heterodimer partner (SHP/NR0B2), and the la...
ORGANISM(S): Mus musculus 
2022-04-22 | GSE197549 | GEO
TranscriptomicsA genetic screen identifies hypothalamic Fgf15/19 as a regulator of glucagon secretion
The counterregulatory response to hypoglycemia, which restores normal blood glucose levels to ensure sufficient provision of glucose to the brain, is critical for survival. To discover underlying brain regulatory systems, we performed a genetic screen in recombinant inbred mice for quantitative trai...
ORGANISM(S): Mus musculus 
2016-11-07 | GSE87586 | GEO
TranscriptomicsIntestinal FGF15/19 physiologically represses hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
Hepatic lipogenesis is normally tightly regulated but is aberrantly elevated in obesity. Fibroblast Growth Factor-19 (FGF19, mouse FGF15) is a late fed-state gut hormone that decreases hepatic lipid levels by unclear mechanisms. We examined whether FGF15/19 and FGF15/19-activated Small Heterodimer P...
ORGANISM(S): Mus musculus 
2020-09-23 | GSE158359 | GEO
GenomicsIntestinal FGF15/19 physiologically represses hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
Intestinal FGF15/19 physiologically represses hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
PRJNA664994 | ENA
UnknownFeeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut.
Not available
S-EPMC9434102 | biostudies-literature
UnknownIntestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance.
Not available
S-EPMC11128213 | biostudies-literature
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