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TranscriptomicsTranscription profiling of mouse deficient for Fibrillin-1
Different fibrillin-1 mutant mice
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1852 | biostudies-arrayexpress
TranscriptomicsFibrillin-1 deficient mice
Different fibrillin-1 mutant mice Keywords: other
ORGANISM(S): Mus musculus 
2004-10-20 | GSE1852 | GEO
ProteomicsSecretome analysis of mouse fibroblast
Fibrillin-1, an extracellular matrix (ECM) protein encoded by FBN1 gene, serves as the microfibril scaffold crucial for elastic fiber formation and homeostasis in pliable tissue such as the skin. Besides causing Marfan syndrome, some mutations in FBN1 result in scleroderma, marked by hardened and th...
ORGANISM(S): Mus Musculus (mouse) 
2025-04-11 | PXD052580 | JPOST Repository
GenomicsMus musculus
Fibrillin-1 deficient mice
PRJNA90469 | ENA
GenomicsThe RGD sequence in fibrillin-1 regulates miRNA expression
Fibrillins are the major components of microfibrils in the extracellular matrix of elastic and non-elastic tissues. Fibrillin-1 contains one evolutionarily conserved Arg-Gly-Asp (RGD) sequence which mediates cell-matrix interactions through cell-surface integrins. Mutations in close vicinity to the ...
ORGANISM(S): synthetic construct Homo sapiens 
2018-12-10 | GSE82083 | GEO
TranscriptomicsThe RGD sequence in fibrillin-1 regulates mRNA expression
Fibrillins are the major components of microfibrils in the extracellular matrix of elastic and non-elastic tissues. Fibrillin-1 contains one evolutionarily conserved Arg-Gly-Asp (RGD) sequence which mediates cell-matrix interactions through cell-surface integrins. Mutations in close vicinity to the ...
ORGANISM(S): Homo sapiens 
2018-12-10 | GSE82079 | GEO
ProteomicsProteomic analysis of primary human microvascular endothelial cells (HMVECs) stimulated for 24 h with either 50 ï�g/mL recombinant Fibrillin-1 C-terminal fragment or 25 ng/ml VEGF-A compared to unstimulated cells.
Mutations in the fibrillin-1 gene result in cardiovascular, ocular, and skeletal abnormalities in Marfan syndrome. Here we show that a fibrillin-1 mutation also alters the neovessel formation. In the mouse retina vascularization model, fibrillin-1 is detected at the basement membrane underlying the ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-31 | PXD029834 | Pride
Endothelial cell Quantitative proteome Angiogenesis 
UnknownMicroenvironmental regulation by fibrillin-1.
Not available
S-EPMC3252277 | biostudies-literature
UnknownMaterial and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.
Not available
S-EPMC3097426 | biostudies-literature
ProteomicsPOGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of FBN1
Fibrillin-1 (FBN1) is the major component of extracellular matrix microfibrils, which are required for proper development of elastic tissues including heart and lung. Through protein-protein interactions with latent TGF-beta binding protein 1 (LTBP1), microfibrils assist regulation of TGF-beta signa...
ORGANISM(S): Homo sapiens (Human) 
2021-08-06 | PXD025725 | Pride
Extracellular matrix protein Egf repeats Mass spectrometry Glycosylation Protein secretion Protein folding 
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