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GenomicsThe dynamics of DNA methylation fidelity during mouse embryonic stem cell renewal and differentiation
Purpose: we aimed to gain a genome-wide view of the dynamics in DNA methylation inheritance and define the factors associated with methylation fidelity. Methods: Using mouse embryonic stem cell (ES-E14TG2a) in both undifferentiated and differentiated states as a model system, we exploited the hairpi...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-48229 | biostudies-arrayexpress
ProteomicsCircadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
We describe circadian clock-dependent changes in ribosome composition in Neurospora crassa depending on cell type, stress, or developmental state. Mass spectrometry of ribosomes isolated at different circadian times identified six ribosomal proteins and one ribosome-associated protein with clock-con...
ORGANISM(S): Neurospora Crassa (ncbitaxon:5141) 
2024-10-15 | MSV000096101 | MassIVE
GenomicsTet2 negatively regulates memory fidelity
Tet2 negatively regulates memory fidelity
PRJNA590200 | ENA
ProteomicsAltered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia
Genomic studies have recently identified RPS15 as a new driver gene in aggressive and chemorefractory cases of chronic lymphocytic leukemia (CLL). RPS15 encodes a ribosomal protein whose conserved C-terminal domain extends into the decoding center of the ribosome. We demonstrate that mutations in hi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD010924 | Pride
Chronic lymphocytic leukemia Translational fidelity Ribosomal decoding center Cll Rps15 Proteostasis 
GenomicsPRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation (RRBS)
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation, an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs ...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-53507 | biostudies-arrayexpress
ProteomicsHuman TRMT2A methylates different components of the translation machinery and contributes to translation fidelity
Methyl-5-uridine (m5U) is one of the most abundant RNA modifications found in cytosolic tRNA. tRNA methyltransferase 2 homolog A (hTRMT2A) is the dedicated mammalian enzyme of m5U conversion at tRNA position 54. However, its RNA binding specificity and functional role in the cell are not well unders...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD036538 | Pride
Rna biogenesis Translational fidelity Methyl-5-uridine (m5u) Rna methylation Trna methyltransferase 2 homolog a (htrmt2a) Interactome Mammalia 
TranscriptomicsPRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation (RNA-Seq)
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation, an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs ...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-53506 | biostudies-arrayexpress
GenomicsPRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation (ChIP-Seq)
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation, an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs ...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-53505 | biostudies-arrayexpress
UnknownHypokalaemia in patients with type 2 diabetes and chronic kidney disease: the effect of finerenone-a FIDELITY analysis.
Not available
S-EPMC11805688 | biostudies-literature
GenomicsRRBS-based quantitative methylation analysis define 100% methylation fidelity CpG sites
RRBS-based quantitative methylation analysis define 100% methylation fidelity CpG sites
PRJNA735782 | ENA
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