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TranscriptomicsExpression data from rat urinary bladder and non-glandular stomach tissue samples
Seven novel and potent Raf small molecule kinase inhibitors were evaluated in 7-day oral repeat-dose rat toxicity studies. All compounds tested induced hyperplasia in multiple tissues. Microarrays were used to investigate transciptional changes associated by treatment with a single compound to gain ...
ORGANISM(S): Rattus norvegicus 
2011-07-18 | E-GEOD-26936 | biostudies-arrayexpress
ProteomicsMetalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Removal
Cytotoxicity of DNA-protein crosslinks (DPCs) is ascribed largely to their ability to block the progression of DNA replication fork. DPCs are frequently occurring in cells, either as a consequence of metabolism or exogenous agents. The mechanism of DPCs removal is not completely understood. Here, we...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080743 | MassIVE
TranscriptomicsDevelopment of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection
Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understand Mechanisms of Chemical Toxicity and Action These data support the publication titled "Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understa...
ORGANISM(S): Rattus norvegicus 
2005-05-31 | E-GEOD-2409 | biostudies-arrayexpress
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