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MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
ProteomicsSoluble SORLA enhances neurite outgrowth and regeneration through activation of EGFR and MAPK pathways
SORLA is a type I transmembrane component associated with Alzheimers disease (AD) risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain yet unclear. Here, we show that cultured neurons overexpressing SORLA (SORLA TG) feature enhanced neurite length, and accele...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-05-12 | MSV000085400 | MassIVE
TranscriptomicsExpression of MERTK based on Multiple Sclerosis (MS) risk haplotype
Whole transcriptome RNA-seq analysis to measure group-wise RNA expression level of the MERTK gene in 3 healthy controls (known to be homozygous non-risk haplotype at MERTK gene locus) and to compare this to the group-wise RNA expression level of the MERTK gene in 5 Multiple Sclerosis-affected (MS-af...
ORGANISM(S): Homo sapiens 
2016-02-06 | E-GEOD-77598 | biostudies-arrayexpress
TranscriptomicsGene Expression in Frontal Cortex in Major Depression and HIV
Major depressive disorder (MDD) is a clinically defined entity with little understanding as to the underlying pathological substrate. Biologically, MDD is characterized by disruption of neurotransmitters, especially serotonin and noradrenaline, which are the main targets of antidepressants. We pre...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-17440 | biostudies-arrayexpress
ProteomicsIdentification and characterization of the zebra finch (Taeniopygia guttata) sperm proteome
Spermatozoa exhibit remarkable variability in size, shape, and performance. Our understanding of the molecular basis of this variation, however, is limited, especially in avian taxa. The zebra finch (Taeniopygia guttata) is a model organism in the study of avian sperm biology and sperm competition. ...
ORGANISM(S): Taeniopygia guttata (Zebra finch) (Poephila guttata) 
2025-09-16 | PXD067397 | Pride
Avian sperm passerines sexual reproduction sperm proteins positive selection 
GenomicsRSC and ISW1 Chromatin Remodelers Display Functional and Chromatin-based Promoter Antagonism [ChIP-seq]
ISWI-family chromatin remodelers organize nucleosome arrays, while SWI/SNF-family remodelers (RSC) disorganize and eject nucleosomes, implying an antagonism that is largely unexplored in vivo. Here, we describe two independent genetic screens for rsc suppressors that yielded mutations in the promote...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-01 | E-GEOD-65592 | biostudies-arrayexpress
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