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TranscriptomicsEffects of long dsRNA expression in HeLa and HEK293 cells
Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, including sequence-specific RNA interference, sequence-independent interferon response and editing by adenosine deaminases. To assess the potential of expressed dsRNA to induce interferon stimulated genes in somatic cells, ...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-27316 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HEK-293 cells to identify Dicer and Argonaute regulated gene expression
HEK-293-derived cell lines depleted of Dicer or one of four Argonaute proteins were generated. Microarray analysis of these knock down cell lines and various control cell lines was performed to address how large the proportion of genes is that are regulated by RNA silencing in an individual cell typ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4246 | biostudies-arrayexpress
TranscriptomicssiRNA of mouse undifferentiated Dicer -/- (27H10) embryonic stem cells
We have analyzed the transcript expression levels in Dicer knock-out embryonic stem (ES) cells 24 hours after transfection with either control siRNA agains Renilla luciferase or miRNA Mimics (Dharmacon) of mmu-miR-290 cluster members in order to identify primary targets of miR-290 cluster miRNAs. Ex...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8503 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse undifferentiated Dicer +/- (D4) and Dicer -/- (27H10) embryonic cell lines
We have analyzed the transcript expression levels in Dicer heterozygous and Dicer knock-out embryonic stem (ES) cells in order to identify which transcripts are regulated by RNAi pathway in mouse ES cells. Experiment Overall Design: Two cell lines were analysed in an undifferentiated state. Triplic...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7141 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile in mouse cone photoreceptors at P60 [miRNA-seq]
The outer segments of cones serve as light detectors for daylight color vision, and their dysfunction leads to human blindness conditions. We show that the cone-specific disruption of DiGeorge Syndrome Critical Region Gene 8 (DGCR8) in adult mice led to the loss of miRNAs and the loss of outer segme...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-58500 | biostudies-arrayexpress
TranscriptomicsExpression data of wild type and C-DGCR8 KO cones at different timepoints [array]
We have analyzed gene expression in cone photoreceptors isolated from wild type and C-DGCR8 (DiGeorge Syndrome Critical Region Gene 8) KO mice at five different time points to get a mechanistic inside into the altered molecular pathways after microRNAs depletion. Cones were isolated by FACS from wil...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-58493 | biostudies-arrayexpress
TranscriptomicsExpression data of wild type and C-DGCR8 KO cones at different timepoints [RNA-seq]
We have analyzed gene expression in cone photoreceptors isolated from wild type and C-DGCR8 (DiGeorge Syndrome Critical Region Gene 8) KO mice at five different time points to get a mechanistic inside into the altered molecular pathways after microRNAs depletion. Cones were isolated by FACS from wil...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-58498 | biostudies-arrayexpress
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