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TranscriptomicsPromiscuous targeting of bromodomains by Bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78830 | biostudies-arrayexpress
TranscriptomicsPromiscuous targeting of bromodomains by Bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia [set 1]
Bromodomains (BRDs) have emerged as compelling targets for cancer therapy. The development of selective and potent BET inhibitors and their significant activity in diverse tumor models has rapidly translated into clinical studies and has motivated drug development efforts targeting non-BET BRDs. How...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78827 | biostudies-arrayexpress
TranscriptomicsPromiscuous targeting of bromodomains by Bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia [set2]
Bromodomains (BRDs) have emerged as compelling targets for cancer therapy. The development of selective and potent BET inhibitors and their significant activity in diverse tumor models has rapidly translated into clinical studies and has motivated drug development efforts targeting non-BET BRDs. How...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78829 | biostudies-arrayexpress
Proteomics,MultiomicsLambert_P82_VS6_ZMYND8_reader_APMS_BioID_01OCT2015
This submission contains the mass spectrometry files for the manuscript by Filippakopoulos and colleges that characterize ZMYND8 by AP-MS and BioID. This submission contains 56 DDA files for the following baits: empty 3XFLAG control, GFP-BirA-FLAG control, NLS-BirA-FLAG control, 3xFLAG-ZMYND8 and 3x...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-10-01 | MSV000079336 | MassIVE
TranscriptomicsEffect of BET inhibitors (JQ1 and RVX-208) on gene expression in HepG2 cells
Bromodomains have emerged as attractive candidates for the development of inhibitors targeting gene transcription. Inhibitors of the bromo-and-extra-terminal (BET) family recently showed promising activity in diverse disease models. However, the pleiotropic nature of BET proteins regulating tissue s...
ORGANISM(S): Homo sapiens 
2013-09-24 | E-GEOD-51143 | biostudies-arrayexpress
ProteomicsSAINT_3727_JQ1_APMS_endoK562_P82_VS17_28AUG2018
This submission contains the mass spectrometry files for the manuscript by Lambert, Picaud et al. that describes the characterization of interactome changes induced by JQ1 on the BET proteins. This submission contains 16 files associated with endogenous IP-MS analysis of BRD2, BRD3 and BRD4 (IgG was...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-28 | MSV000082859 | MassIVE
ProteomicsLambert_BRD_SAINT2307_JQ1_APMS_time_course_TripleTOF_P82_VS5
This submission contains the mass spectrometry files for the manuscript by Lambert, Picaud et al. that describes the characterization of interactome changes induced by JQ1 on the BET proteins. More precisely, files used in the SAINT express task 2307 are in this dataset. The AP-MS experiments involv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-25 | MSV000081006 | MassIVE
ProteomicsSAINT_3726_JQ1_APMS_endoHEK293_P82_VS16_28AUG2018
This submission contains the mass spectrometry files for the manuscript by Lambert, Picaud et al. that describes the characterization of interactome changes induced by JQ1 on the BET proteins. This submission contains 16 files associated with endogenous IP-MS analysis of BRD2, BRD3 and BRD4 (IgG was...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-28 | MSV000082857 | MassIVE
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