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TranscriptomicsTranscription profiling of mouse skeletal muscle overexpressing PPARalpha
This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor alpha (PPARa) in skeletal muscle of transgenic mice that overexpressed PPARa. The following abstract from the published manuscript describes the major findings of this work. A potential link betw...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5777 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver overexpressing lipin 1beta
Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld mice, a genetic model of lipodystrophy. Lipin 1 appears to be highly involved in the control of fatty acid metabolism. Lipin 1 is most often located in the nucleus, but other studies suggest that lipin also has effects in the cyto...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5538 | biostudies-arrayexpress
TranscriptomicsInhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice
Abnormalities in hepatic lipid metabolism are believed to play a critical role in the etiology of nonalcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) sy...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-60349 | biostudies-arrayexpress
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