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TranscriptomicsSolitary Fibrous Tumours gene profiling study
Using whole-genome DNA microarrays, we defined the gene expression profiles of 16 Solitary Fibrous Tumours (SFT) and haemangiopericytomas (HPC) (9 HPC and 7 SFT). Expression profiles were compared to publicly available expression profiles of additional SFT or HPC, meningiomas and synovial sarcomas.
ORGANISM(S): Homo sapiens 
2023-02-08 | E-MTAB-11447 | biostudies-arrayexpress
TranscriptomicsA gene expression signature identifies two prognostic subgroups of basal breast cancer
Medullary breast cancers (MBC) display a basal profile, but a favorable prognosis. We hypothesized that a previously published 368-gene expression signature associated with MBC might serve to define a prognostic classifier in basal cancers. We collected public gene expression and histoclinical data ...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-21653 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of solitary fibrous tumors
Sixteen pre-treatment samples of pathologically confirmed solitary fibrous tumors (SFT) were available for RNA profiling. They were collected from 16 patients who underwent initial surgery and/or diagnostic biopsy. Samples were macrodissected by pathologists, and frozen within 30 min of removal in l...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-MTAB-1361 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of castration-resistant prostate cancer PC-3 cells treated with Hsp27-siRNA or control siRNA to study the role of Heat shock protein (Hsp) 27 in splicing
In order to investigate the involvement of Hsp27 in splicing, we performed a whole-genome exonic expression profiling of the castration-resistant prostate cancer PC-3 cells treated by Hsp27-siRNA or CTL-siRNA (both in biological duplicates).
ORGANISM(S): Homo sapiens 
2015-06-30 | E-MTAB-1786 | biostudies-arrayexpress
UnknownA gene expression signature identifies two prognostic subgroups of basal breast cancer
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-21653 | biostudies-other
TranscriptomicsGene expressionprofiling of breast cell lines
We performed gene expression profiling of 31 breast cell lines (BCL) using whole-genome DNA microarrays (Affymetrix U133+2.0) to assessed a better molecular characterization of breast cell lines in order to help discover of new markers to apply to tumour samples.
ORGANISM(S): Homo sapiens 
2013-06-10 | E-MTAB-1693 | biostudies-arrayexpress
TranscriptomicsHigh-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genes
Inflammatory breast cancer (IBC) is an aggressive form of BC poorly defined at the molecular level. We compared the molecular portraits of 63 IBC and 134 non-IBC (nIBC) clinical samples. Genomic imbalances of 49 IBCs and 124 nIBCs were determined using high-resolution array-comparative genomic hybri...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-23720 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human classical Hodgkinas lymphoma tissues
Previous reports suggest that outcome of cHL patients may be related to the tumor microenvironment, which in turn may be influenced by EBV infection. Gene profiling was used for further characterize the cHL microenvironment. A training set of 73 cHL tissue samples was profiled using Affymetrix DNA m...
ORGANISM(S): Homo sapiens 
2009-01-06 | E-GEOD-13996 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pancreatic cancer treated with masitinib combined with standard gemcitabine chemotherapy
Masitinib is a tyrosine kinase inhibitor of c-Kit, PDGFRα and β, and to some extent Lyn of the Src kinase family. We evaluated the therapeutic potential of masitinib in vitro on human pancreatic tumour cell lines and in vivo in a mouse model of human pancreatic cancer. Experiment Overall Design: E...
ORGANISM(S): Homo sapiens 
2009-09-17 | E-GEOD-17987 | biostudies-arrayexpress
TranscriptomicsPediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KITphosphotransferase domain mutations.
Most adult patients have a D816V mutation in phosphotransferase domain (PTD), we have described that half of the children carry mutations in extracellular domain (ECD). KIT-ECD versus IT-PTD-mutants were introduced into rodent Ba/F3, EML, Rat2 and human TF1 cells to investigate their biological effe...
ORGANISM(S): Mus musculus 
2010-04-10 | E-GEOD-21255 | biostudies-arrayexpress
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