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ProteomicsColorectal Cancer Organoid Proteomics
Cyclin Dependent Kinases CDK8 and CDK19 (Mediator kinase) are regulatory components of the Mediator complex, a highly conserved complex that fine tunes transcriptional output. While Mediator kinase has been implicated in the transcriptional control of key pathways necessary for development and growt...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD030256 | Pride
Mouse Colorectal cancer Proteomics 
TranscriptomicsPRPF6 regulated alternative splicing in colon cancer cell lines
PRPF6, an RNA binding component of the pre-mRNA spliceosome, is an essential driver of oncogenesis in colon cancer. PRPF6 is both amplified and overexpressed in colon cancer and cells with high PRPF6 levels are sensitive to its loss. Here we investigate alternative splicing changes in colon cancer ...
ORGANISM(S): Homo sapiens 
2014-06-18 | E-GEOD-56846 | biostudies-arrayexpress
Genomicsena-DATASET-Genentech-07-04-2014-17:40:39:195-163 - samples
Alternative splicing plays critical roles in differentiation, development, and cancer (Pettigrew et al., 2008; Chen and Manley, 2009). The recent identification of specific spliceosome inhibitors has generated interest in the therapeutic potential of targeting this cellular process (van Alphen et al...
EGAD00001000817 | EGA
GenomicsRNAseq data to study PRPF6 regulated splice forms in colon cancer cell lines
Alternative splicing plays critical roles in differentiation, development, and cancer (Pettigrew et al., 2008; Chen and Manley, 2009). The recent identification of specific spliceosome inhibitors has generated interest in the therapeutic potential of targeting this cellular process (van Alphen et al...
EGAS00001000761 | EGA
GenomicsGenentech gastric cell line sequencing - samples
SNP array data for gastric cancer cell lines
EGAD00010000622 | EGA
Genomicsena-DATASET-Genentech-03-04-2014-21:11:45:639-54 - samples
Exome-seq, RNA-Seq, SNP array profiling of gastric tumor samples.
EGAD00001000815 | EGA
GenomicsExome-seq, RNA-Seq, SNP array profiling of gastric tumor samples and cell lines.
Gastric cancer is the second leading cause of worldwide cancer mortality, yet the underlying genomic alterations remain poorly understood. Here we performed exome and transcriptome sequencing and SNP array assays to characterize 51 primary gastric tumors and 32 cell lines. Meta-analysis of the exome...
EGAS00001000736 | EGA
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