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MetabolomicsIntestinal Bacillus sp. derived IBA activates PPARγ to promote PUFA synthesis in fish

Background: Marine fish are paradoxically rich in polyunsaturated fatty acids (PUFAs) despite their limited endogenous biosynthesis capacity, suggesting a critical role of exogenous acquisition or microbial contributions.

Results: Here, we characterized the gut microbiota of Seriola dumeri...

2026-02-09 | MTBLS13872 | MetaboLights
MetabolomicsA multi-omics approach to study peroxisome proliferator-activated receptor mediated regulation of lipid metabolism in Atlantic cod (Gadus morhua)
Lipid metabolism is essential in maintaining energy homeostasis in multicellular organisms. In vertebrates, a group of nuclear receptor transcription factors named peroxisome proliferator-activated receptors (PPARs, NR1C) regulate the expression of many genes involved in these processes. We have rec...
2022-02-28 | MTBLS2131 | MetaboLights
TranscriptomicsGenotype-specific responses in intestinal lipid metabolism to complete dietary fish oil replacement by vegetable oil in Atlantic salmon
As part of a study investigating the effects of genotype on responses to sustainable feeds in Atlantic salmon, a microarray analysis of the intestine transcriptome of two family groups, identified as 'Lean' or 'Fat' (based on flesh lipid content), which were fed a diet containing either 100% fish oi...
ORGANISM(S): Salmo salar 
2012-03-01 | E-TABM-1173 | biostudies-arrayexpress
MetabolomicsLipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a high-fat diet (HFD). LC-MS/MS at levels of lip...
2014-08-19 | MTBLS26 | MetaboLights
MetabolomicsThe impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes
We showed earlier that nutritional stress like starvation or high fat diet resulted in phenotypic changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the pathophysiological status of the mouse model. Here we extend our former study by adding genetic stress due to knock-ou...
2014-08-19 | MTBLS81 | MetaboLights
TranscriptomicsTranscription profiling of Atlantic salmon following dietary substitution of fish oil with vegetable oils
There is an increasing drive to replace fish oil (FO) in finfish aquaculture diets with vegetable oils (VO), driven by the short supply of FO derived from wild fish stocks. Little is known of the consequences for fish health after such substitution. The effect of dietary VO on hepatic gene expressio...
ORGANISM(S): Salmo salar 
2008-10-27 | E-TABM-478 | biostudies-arrayexpress
TranscriptomicsGenotype-specific responses in hepatic lipid metabolism to complete dietary fish oil replacement by vegetable oil in Atlantic salmon
As part of a study investigating the effects of genotype on responses to sustainable feeds in Atlantic salmon, a microarray analysis of the liver transcriptome of two family groups, identified as 'Lean' or 'Fat' (based on flesh lipid content), which were fed a diet containing either 100% fish oil (F...
ORGANISM(S): Salmo salar 
2011-01-04 | E-TABM-1089 | biostudies-arrayexpress
MetabolomicsEffects of Ultra-fine Pulverized Mulberry Leaf Combined with Multi-enzyme Preparations on Lipid Metabolism in Serum, Liver, Muscle and Intestine of Grass Carp

Grass carp are prone to excessive fat deposition under intensive aquaculture conditions, which impairs their health and reduces the economic benefit of farmed carp. We investigated the effects of dietary ultrafine pulverized mulberry leaf on lipid metabolism in grass carp, using phenotypic indica...

2026-10-15 | MTBLS13847 | MetaboLights
MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
MetabolomicsGlobal ocean lipidomes show a universal relationship between temperature and lipid unsaturation

Global-scale surveys of plankton communities using “omics” techniques have revolutionized our understanding of the ocean. Lipidomics has demonstrated the potential to add further essential insights on ocean ecosystem function but has yet to be applied on a global scale. We analyzed 930 lipid samp...

2021-11-08 | MTBLS2838 | MetaboLights
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