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UnknownThe multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease.
Not available
S-EPMC7855940 | biostudies-literature
UnknownThe absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling.
Not available
S-EPMC12445586 | biostudies-literature
UnknownTargeting APE1 endonuclease activity impairs metastasis and enhances genotoxic therapy response in pancreatic cancer.
Not available
S-EPMC12776480 | biostudies-literature
UnknownRef-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization.
Not available
S-EPMC7250474 | biostudies-literature
UnknownIn vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer.
Not available
S-EPMC10749280 | biostudies-literature
UnknownActivation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment.
Not available
S-EPMC10174294 | biostudies-literature
UnknownFast-Relaxing Hydrogels Promote Pancreatic Adenocarcinoma Cell Aggressiveness through Integrin β1 Signaling.
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S-EPMC11817685 | biostudies-literature
UnknownNew Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types.
Not available
S-EPMC10962275 | biostudies-literature
UnknownRef-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target.
Not available
S-EPMC8353735 | biostudies-literature
UnknownDrug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells.
Not available
S-EPMC9776744 | biostudies-literature
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