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ProteomicsPhospholipids with two polyunsaturated fatty acyl tails drive ferroptosi.
Phospholipids containing polyunsaturated fatty acyl tails (PL-PUFAs) are susceptible to lipid peroxidation by reactive oxygen species, lipoxygenases, and radical species. The accumulation of peroxidized lipids in cell membranes overwhelms endogenous lipid repair processes and triggers ferroptosis. W...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD041993 | Pride
Polyunsaturated fatty acid  pufa  phospholipid  mitochondria  complex i  ros  ferroptosis  lipids 
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
ProteomicsTransferrin receptor is a specific ferroptosis marker
Ferroptosis is a form of regulated cell death driven by the iron-dependent accumulation of oxidized polyunsaturated-fatty-acid-containing phospholipids (PUFA-PLs). Three key molecular features of ferroptosis are peroxidation of PUFA-PLs, accumulation of redox-active ferrous iron, and defective lipid...
ORGANISM(S): Homo sapiens (Human) 
2020-03-10 | PXD017425 | Pride
Antigen Ip-msms Ferroptosis 
TranscriptomicsCardiac transcriptomic shifts during first 24h of thermal acclimation in the porcelain crab, Petrolisthes cinctipes
Intertidal zone organisms can experience transient freezing temperatures during winter low tides, but their extreme cold tolerance mechanisms are not known. Petrolisthes cinctipes is a temperate mid-high intertidal zone crab species that can experience wintertime habitat temperatures below the free...
ORGANISM(S): Petrolisthes cinctipes 
2012-03-01 | E-GEOD-35307 | biostudies-arrayexpress
TranscriptomicsThe clinical and molecular significance of different types of C4d staining in renal allografts
We investigated the clinical and molecular significance of minimal peritubular capillary (PTC) and isolated glomerular C4d+ staining using microarrays. Immunohistochemistry for C4d was performed on paraffin-embedded sections. Of the 255 biopsies analyzed, 51% were C4d negative, 4% were minimal, 15% ...
ORGANISM(S): Homo sapiens 
2012-05-28 | E-GEOD-38262 | biostudies-arrayexpress
UnknownAn integrated encyclopedia of DNA elements in the human genome.
Not available
S-EPMC3439153 | biostudies-literature
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