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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsInterferon-related transcriptional program is induced by chronic hepatitis E infection in kidney-transplant recipients
Background: Hepatitis E Virus (HEV) is a new causative agent of chronic hepatitis in solid organ transplant recipients in Europe. Factors associated with the occurrence and persistence of chronic HEV infection remain largely unknown but chronic evolution seems to be the consequence of hostM-bM-^@M-^...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-36539 | biostudies-arrayexpress
TranscriptomicsEnterococcus faecalis OG1RF control vs. treatment with vancomycin
Transcriptional profiling to investigate the effect of drug treatment on the E. faecalis cells. For microarray analysis, E. faecalis OG1RF was grown in FMC medium supplemented with 10 mM glucose to an optical density at 600 nm (OD600) of 0.3 and the cultures were divided in 3 aliquots. One aliquot...
ORGANISM(S): Enterococcus faecalis OG1RF 
2013-03-19 | E-GEOD-45300 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse embryonic stem cells with knockout of Nhlrc2 gene or addition of FINCA disease causing NHLRC2 p.Asp148Tyr variant
Fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA) (OMIM 618278) is a rare infantile-onset disease caused by variants in NHL repeat containing 2 (NHLRC2) gene. NHLRC2 is essential for mouse gastrulation (Hiltunen et al., 2022). Here, RNA sequencing was performed on four wild type (WT), f...
ORGANISM(S): Mus musculus 
2025-05-22 | E-MTAB-14174 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the thermophilic biomass-degrading fungus Malbranchea cinnamomea FCH 10.5 when grown on glucose, wheat bran and beechwood xylan
The thermophilic fungus Malbranchea cinnamomea belongs to the order of Onygenales and is a promising source of thermostable, industrially relevant biocatalysts, as it can grow at temperatures of more than 50°C and is able to utilise many different types of plant biomass. Enzymes from M. cinnamomea t...
ORGANISM(S): Malbranchea cinnamomea 
2017-10-27 | E-MTAB-6157 | biostudies-arrayexpress
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
TranscriptomicsStreptococcus mutans UA159 with or without 8.4% oxygen vs. nox mutant strain. pH5
Transcriptional analysis of the effects of oxygen concentraion in S. mutans RNA was extracted from 3 or 4 replicate samples of S. mutans UA159, UA159 grown in 8.4 % oxygen concentration and MU1020 (M-bM-^HM-^Fnox) grown in continuous culture to steady-state pH values of 5. RNA was labeled with Cy3....
ORGANISM(S): Streptococcus mutans UA159 
2014-04-01 | E-GEOD-56118 | biostudies-arrayexpress
TranscriptomicsLytic infection of Lactococcus lactis by bacteriophages Tuc2009 and c2 trigger alternative transcriptional host responses
This study analysed the temporal transcriptional response of L. lactis UC509.9 undergoing infection with either Tuc2009 or c2, representing phages of two different species (P335 and c2, respectively) of the family Siphoviridae. For the first time, to our knowledge, both DNA microarrays of the host a...
ORGANISM(S): Lactococcus lactis subsp. cremoris UC509.9 
2013-06-27 | E-GEOD-45655 | biostudies-arrayexpress
UnknownInternational pilot external quality assessment scheme for analysis and reporting of circulating tumour DNA.
Not available
S-EPMC6085634 | biostudies-literature
TranscriptomicsStreptococcus mutans UA159 with or without 8.4% oxygen vs. nox mutant strain. pH7
Transcriptional analysis of the effects of oxygen concentraion in S. mutans RNA was extracted from 3 or 4 replicate samples of S. mutans UA159, UA159 grown in 8.4 % oxygen concentration and MU1020 (M-bM-^HM-^Fnox) grown in continuous culture to steady-state pH values of 7. RNA was labeled with Cy3....
ORGANISM(S): Streptococcus mutans UA159 
2012-10-04 | E-GEOD-38803 | biostudies-arrayexpress
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