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MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
MetabolomicsIntracellular iron overload rewires HSC metabolism by impairing mitochondrial fitness
Iron is an essential element for several cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). When in excess it reduces quiescence and self-renewal, however, whether and how iron influences HSC metabolism is still unknown. Here, w...
2024-12-04 | MTBLS11778 | MetaboLights
ProteomicsCompensating the fitness costs of synonymous mutations
Synonymous mutations do not change the sequence of the polypeptide but they may still influence fitness. We investigated in Salmonella enterica how four synonymous mutations in the rpsT gene (encoding ribosomal protein S20) reduce fitness (i.e. growth rate) and the mechanisms by which this cost can...
ORGANISM(S): Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
2016-03-11 | PXD003495 | Pride
Salmonella mutations Rpst gene Ribosomal protein s20 
ProteomicsResource misallocation as a mediator of fitness costs in antibiotic resistance
Antimicrobial resistance (AMR) poses a threat to global health and the economy. Rifampicin resistant Mycobacterium tuberculosis accounts for a third of the global AMR burden. Gaining the upper hand on AMR requires a deeper understanding of the physiology of resistance. AMR often results in the eros...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2021-03-12 | PXD011568 | Pride
Genomics Clinical isolates Mycobacterium tuberculosis Systems biology Transcriptomics Drug resistance Proteomics 
GenomicsInsecticide resistance fitness costs in D. simulans
Fitness effects for Ace insecticide resistance mutations are determined by ambient temperature
PRJEB39894 | ENA
GenomicsRNA m6A methylation suppresses insect juvenile hormone degradation to minimize fitness costs in response to a pathogenic attack
RNA m6A methylation suppresses insect juvenile hormone degradation to minimize fitness costs in response to a pathogenic attack
PRJNA1036232 | ENA
OtherRNA m6A methylation suppresses insect juvenile hormone degradation to minimize fitness costs in response to a pathogenic attack
Bioinsecticides and transgenic crops based on the bacterial pathogen Bacillus thuringiensis (Bt) can effectively control diverse agricultural insect pests, nevertheless, insect resistance evolution without causing obvious fitness costs has seriously eroded the sustainable use of these Bt products. R...
ORGANISM(S): Plutella xylostella 
2023-11-10 | GSE247107 | GEO
TranscriptomicsPhenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance
In vitro studies have described metronidazole (MTZ) resistance and the potential mechanisms involved. Costs to fitness and adaptive responses associated with resistance, however, have not been investigated. In this study we generated an HM-1-derived strain resistant to 12 µM MTZ (MTZR). We examined ...
ORGANISM(S): Entamoeba histolytica 
2012-02-22 | E-GEOD-35990 | biostudies-arrayexpress
ProteomicsSuppressed Protein Translation Caused by MSP-8 Defect Determines Fungal Multidrug Resistance with Fitness Cost
Antifungal resistance, particularly the rise in multidrug resistance, has become a critical public health concern, garnering substantial attention. In this study, we used experimental evolution with Neurospora crassa as a model and identified a novel multidrug-resistance gene, msp-8, which encodes a...
ORGANISM(S): Neurospora Crassa Or74a 
2024-08-02 | PXD054574 |
GenomicsMeiotic cohesin Rec8 imposes fitness costs on fission yeast gametes to drive evolution of parental bias in gene expression
Meiotic cohesin Rec8 imposes fitness costs on fission yeast gametes to drive evolution of parental bias in gene expression
PRJNA1246565 | ENA
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